慢性乙型肝炎患者不同免疫状态下血清γ谷氨酰转肽酶水平变化及其临床意义  

Expression and clinical significance of serum γ-glutamyltransferase in patients with chronic hepatitis B virus infection in different immune status

作　　者：武抗抗 杨晨辰[1] 黄睿[1] 刘勇[1] 熊亚莉[1] 苏然[1] 曹淑凤[1] 吴超[1] 

机构地区：[1]南京大学医学院附属鼓楼医院感染科,210008

出　　处：《实用医学杂志》2014年第13期2068-2071,共4页The Journal of Practical Medicine

基　　金：江苏省临床医学科技专项(编号:BL2012034);江苏省医学领军人才与创新团队资助项目(编号:LJ201154)

摘　　要：目的:探讨慢性乙型肝炎(CHB)患者不同免疫状态下血清γ谷氨酰转肽酶(γ-GGT)水平与血清HBV DNA载量、ALT之间的关系。方法:收集191例处于不同免疫状态的CHB患者,包括非活动性HBV携带期(B组,55例)、免疫耐受期(C组,47例)、HBeAg阴性CHB(D组,17例)、免疫活化期(E组,72例)及61例健康对照(A组),检测各组患者血清γ-GGT水平,同时检测血清HBV DNA载量及ALT水平。结果 :D、E组γ-GGT水平明显高于A、B、C组(P<0.01)。相关性分析发现,D组和E组γ-GGT与血清ALT、AST水平均呈正相关(P<0.01),与HBV DNA载量无相关性。结论:不同免疫状态下CHB患者γ-GGT水平不同,血清γ-GGT水平升高可能是CHB患者进入免疫活化期的指标,肝脏炎症损伤是影响其水平的主要因素。Objective To observe the serum γ-glutamyhransferase （3,-GGT） levels in patients with chronic hepatitis B virus （HBV） infection in different immune status and investigate their relationship with HBV DNA loads and ALT levels. Methods Blood samples were collected from 191 patients with chronic HBV infection in different immune status, including inactive HBV carrier state （group B, n = 55）, immune tolerance phase （group C, n = 47）, HBeAg-negative CHB （group D, n = 17）, immune-reactive phase （group E, n = 72） and 61 healthy individuals （ group A） for the detection of the serum 3,-GGT, ALT level and HBV DNA loads. Results γ- GGT level were obviously higher in groups D and E than those in groups of A, B and C （P〈0.01）. Correlation analysis showed that the γ-GGT levels were positively correlated with serum ALT , AST levels in HBeAg-negative CHB and immune-reactive phase, but not correlated with HBV DNA loads. Conclusions The levels of γ-GGT are different during different immune status in patients with chronic HBV infection. The increased serum γ-GGT level may be an indicator for patients with chronic HBV infection entering immune active phase. The liver inflammation is the major impact factor to the γ-GGT levels.

关 键 词：肝炎 乙型 慢性 血清γ谷氨酰转肽酶 免疫状态 

分 类 号：R512.62[医药卫生—内科学]