α-硫辛酸治疗急性脑梗死伴2型糖尿病的临床观察  

Clinical Efficacy of the Lipoic Acid Injection Treatment of Acute Cerebral Infarction in Patients with Type 2 Diabetes

作　　者：王利惠[1] 郝冬琳[1] 吴文[1] 毛伦林[1] 王佳佳[1] 

机构地区：[1]常州市武进人民医院神经内科,江苏常州213003

出　　处：《中国卫生标准管理》2014年第5期72-75,共4页China Health Standard Management

摘　　要：目的观察α-硫辛酸治疗急性脑梗死伴2型糖尿病患者的临床疗效。方法将84例急性脑梗死伴2型糖尿病的患者随机分为两组,在试验前均未给予溶栓治疗。两组患者均根据病情给予常规治疗,即抗血小板聚集、降血脂稳定斑块、控制血糖及活血化瘀等治疗。治疗组(42例)在常规治疗基础上加用α-硫辛酸注射液600 mg加入0.9%氯化钠250 ml静滴,1次/日,15天为1个疗程。分别在治疗前、治疗后评定两组患者的NIHSS评分,在12周时评定两组患者的日常生活活动能力(ADL)评分和改良Rankin评分(MRS)。结果 1个疗程治疗结束后,治疗组NIHSS评分(2.74±0.89)分,明显低于对照组的(3.83±2.33)分(P<0.01)。12周时,治疗组ADL巴氏指数评定(Barthel Index)(86.55±6.76)分,明显高于对照组的(81.07±11.92)(P<0.05);治疗组磁共振波谱(MRS)评分(1.02±0.72)分,明显低于对照组的(1.62±0.70)分(P<0.01)。结论α-硫辛酸治疗急性脑梗死伴2型糖尿病患者临床疗效显著,有较好的应用前景。Objective To observe clinical efficacy of the lipoic acid injection treatment of acute cerebral infarction in patients with type 2 diabetes. Methods 84 cases of cerebral infarction patients with type 2 diabetes were divided into treatment group and control group randomly. All the patients of two groups were not given thrombolysis anticoagulation therapy before the trial. The two groups of patients were given routine treatment, such as anti-platelet aggregation, lipid-lowering, blood glucose controlling, and promoting blood circulation, according to the conditions of disease. Additionally, 42 patients in the treatment group received treatment of injection lipoic acid 600 mg, which was added into 250 ml 0.9%NaC1 solution injection, by intravenous drip infusion once daily for 15 days. NIHSS Scale was used to evaluate the clinical efficacy. ADL Scale and Modified R.ankin Scale were used to determine the defect levels after 12 weeks. Results After one course of treatment, The mean NIHSS of the treatment group （2.74 ± 0.89 ） was significantly lower than the control group＇ s （ 3.83 ±2.33 ） （ P 〈0.01 ） . The Barthel Index of ADL in treatment group （ 86.55 ± 6.76 ） was significantly higher than the control group＇ s （81.07 ± 11.92 ） （P〈0.05） .The mean MRS of the treatment group （1.02 ± 0.72 ）was significantly lower than the control group＇ s （1.62±0.70）（P〈0.01） .Conclusion Lipoic acid injection therapy is effective in acute cerebral infarction patients with type 2 diabetes mellitus.

关 键 词：硫辛酸 脑梗死 2型糖尿病 

分 类 号：R473.33[医药卫生—护理学] R587.1[医药卫生—临床医学]