RP-HPLC法测定青蒿琥酯阿莫地喹片中主药的含量  被引量:4

Determination of Artesunate and Amodiaquine Hydrochloride Tablets by RP-HPLC

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作  者:胡志强[1] 蒋锋 姚忠 

机构地区:[1]宜兴市人民医院,江苏宜兴214200 [2]江苏鹏鹞药业有限公司,江苏宜兴214200

出  处:《淮海工学院学报(自然科学版)》2014年第2期59-61,共3页Journal of Huaihai Institute of Technology:Natural Sciences Edition

摘  要:建立RP-HPLC法测定青蒿琥酯阿莫地喹片中主药的含量。色谱柱为安捷伦的C18柱(4.6 mm×15 cm),测定青蒿琥酯的流动相为乙腈-磷酸盐缓冲液,检测波长为210 nm,测定阿莫地喹的流动相为甲醇-磷酸盐缓冲液,检测波长为224 nm。在考察青蒿琥酯(0.5005~2.002 mg/mL)和阿莫地喹(25.03~100.1μg/mL)的质量浓度范围内具有良好的线性关系,r均达到0.999,平均回收率分别为98.6%和99.5%。结果表明,两套分析方法测定主药的含量,结果准确、可靠。A method for the determination of artesunate and amodiaquine hydrochloride tablets by RP-HPLC was established.The agilent C18(4.6 mm×15 cm)column was used,and the detection wavelength of artesunate was 210 nm.The mobile phase of artesunate was acetonitrile and the buffer solution.The detection wavelength of amodiaquine hydrochloride was 224 nm.The mobile phase of amodiaquine hydrochloride was methanol:phosphate buffer.The linear ranges of artesunate (0.500 5-2.002 mg/mL)and amodiaquine hydrochloride (25.03-100.1μg/mL)were good (r=0.999)with the average recovery rates of 98.6%and 99.5%.The method is simple and accurate,and it can be used for the determination of artesunate and amodiaquine hydrochloride tablets.

关 键 词:青蒿琥酯阿莫地喹片 RP—HPLC 青蒿琥酯 阿莫地喹 

分 类 号:R927[医药卫生—药学]

 

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