间日疟原虫氯喹抗性研究进展  

Research progress on Plasmodium vivax chloroquine resistance

作　　者：李江艳[1] 李倩[1] 方强[1] 

机构地区：[1]蚌埠医学院病原生物学教研室、安徽省感染与免疫重点实验室,蚌埠233030

出　　处：《中国血吸虫病防治杂志》2014年第3期326-331,344,共7页Chinese Journal of Schistosomiasis Control

基　　金：美国NIH研究项目(U19AI089672);教育部科学技术研究重点项目(211079);安徽省自然科学基金(1308085MH160);蚌埠医学院研究生科研创新计划项目(Byycxz302)

摘　　要：疟疾仍然是一个严重危害人类健康的公共卫生问题,尤其多见于发展中国家。随着认识的深入,间日疟也获得越来越多的重视。有效的药物治疗是控制疟疾甚至消除疟疾的基石,近年来已有越来越多的间日疟原虫氯喹抗性报道,间日疟原虫氯喹抗性已成为间日疟防治中一个备受关注的问题。本文就间日疟原虫氯喹抗性的分布现状、体内外检测方法和分子检测标志物研究进展进行初步总结。Malaria remains a serious public health problem,especially in developing countries. With the deepening of the un-derstanding of vivax malaria,Plasmodium vivax is also attracting more and more attention. An effective drug treatment is the foun-dation of controlling or even eliminating malaria. In recent years,more and more reports of chloroquine-resistance Plasmodium vivax have been reported. Plasmodium vivax chloroquine resistance has been a focus problem in vivax malaria prevention and treat-ment. In this paper,the research progress on distribution situation,detection methods and molecular markers of Plasmodium vivax chloroquine resistance is summarized.

关 键 词：间日疟原虫 氯喹 抗性 分子标记物 

分 类 号：R531.3[医药卫生—内科学]