低分子肝素皮下注射持续时间对不良反应影响的Meta分析  

Effects of subcutaneous injection duration of heparin on side effects： A Meta- analysis

作　　者：李艳玲[1] 赵滨[1] 刘慧敏[2] 

机构地区：[1]河北医科大学第二医院护理部,石家庄050000 [2]天津武警后勤学院附属医院呼吸科

出　　处：《中国实用护理杂志》2014年第18期59-62,共4页Chinese Journal of Practical Nursing

摘　　要：目的评价低分子肝素皮下注射持续时间对皮下出血和疼痛的影响。方法计算机检索中国期刊全文数据库、中国生物医学文献数据库、中文科技期刊全文数据库、PubMed、Highwire、Sci—el＇iceDirect全文数据库、中国Cochrane图书馆、万方数据库和Google学术搜索。同时手工检索相关专业期刊，纳入低分子肝素皮下注射持续≥30s和≤10s的随机对照实验。对纳入研究进行质量评价并提取有效数据，采用RevMan5．0软件进行Meta分析。结果共纳入12篇文献，合计1986例次。Meta分析结果显示，低分子肝素皮下注射不同持续时间的2组皮下出血发生率比较差异有统计学意义，注射持续30s皮下出血发生率较低；2组疼痛强度比较差异有统计学意义，但结果较不稳定。结论低分子肝素皮下注射持续30s可减少皮下出血的发生，对患者疼痛强度的影响尚需进一步研究。鉴于纳入研究样本量小，论证强度受到一定限制，上述结果有必要进一步开展高质量、大样本随机对照实验予以证实。Objective To evaluate the effect of injection duration on bruising and pain after the subcutaneous injection of heparin. Methods The relevant randomized controlled trials, quasi-randomized controlled trials about subcutaneous heparin injection duration of≥30 s and ≤ 10 s were searched in the databases of CNKI, CBM, VIP Database for Chinese Technical Periodicals, PubMed, Highwire, ScienceDi- reet, Chinese Cochrane Library, Wanfang database and Google. The quality of RCTs was assessed and Meta- analysis was conducted by RevMan 5.0 Software. Results Twelve RCTs involving 1 986 injections were included. The results of Meta-analysis showed that： There was significant difference between the two groups in the occurrence of bruising. The injection duration of 30 s was much better to prevent bruising. Statistical differences existed in pain intensity between the two groups. Conclusions Prolonging the injection dura- tion to 30 s may reduce the occurrence of subcutaneous bruising. There is no enough evidence to draw a conclusion on pain intensity. Adequately, the current study is limited to a small sample, powered and high quality randomized controlled trials are still needed to be conducted.

关 键 词：低分子肝素 皮下注射 注射时间 META分析 

分 类 号：R472[医药卫生—护理学]