不同胰岛素强化治疗方案对血糖控制不佳2型糖尿病的临床疗效观察  

Clinical Efficacy Observation of the Different Intensive Insulin Treatment on Poor Glycemic Control in Type 2 Diabetes

作　　者：叶启宝 王国娟 陈丽 何媛媛 司玮 马维青 

机构地区：[1]合肥市滨湖医院,安徽合肥230061

出　　处：《中外医学研究》2014年第18期17-18,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究不同胰岛素强化治疗方案对血糖控制不佳2型糖尿病的临床疗效差异。方法:80例2型糖尿病患者随机分为两组,A组给予甘精胰岛素联合赖脯胰岛素皮下注射治疗,B组给予胰岛素泵持续皮下输注胰岛素治疗,比较两组降糖效果、达标时间、胰岛素使用量和低血糖事件发生率。结果:治疗后两组FPG、2 h PG、胰岛素用量比较差异均无统计学意义(P>0.05);达标时间B组明显短于A组(P<0.01),低血糖事件发生率B组低于A组(P<0.05)。结论:采用胰岛素泵持续皮下胰岛素输注的方法能有效模拟人的生理胰岛素分泌,有效控制高血糖,尽早使血糖平稳达标,且低血糖发生率较低。Objective：To study the clinical effects of different intensive insulin treatment on poor glycemic control in type 2 diabetes.Method：80 patients with T2DM were randomly divided into two groups.The patients in group A were given Insulin Glargine combined with Insulin Lispro,and the patients in group B were given insulin pump therapy with Insulin Lispro.The treatment effectiveness,time to target glucose,Insulin dosage and hypoglycaemia incidence in both groups were compared.Result：The levels of fasting blood glucose,2-hour postprandial glucose and insulin dosage all not statistically significant between two groups after therapy（P〉0.05）.The time of target glucose was obviously shorter in group B than group A（P〈0.01）.The hypoglycaemia incidence was lower in group B than group A（P〈0.05）.Conclusion：Continuous subcutaneous Insulin infusion could imitate the physiological insulin secretion control the hyperglycemia effectively, blood glucose stable standard faster and reduced hypoglycemia risk.

关 键 词：2型糖尿病 强化治疗 

分 类 号：R587.1[医药卫生—内分泌]