285株侵袭性真菌感染的临床分布与耐药性分析  

Analysis of Clinical Distribution and Drug Resistance of 285 Strains of Invasive Fungal Infection

作　　者：吴春芳[1] 林养[1] 林荣华[1] 黄诗韵[1] 

机构地区：[1]湛江市第四人民医院,广东湛江524000

出　　处：《中外医学研究》2014年第18期57-59,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:了解侵袭性真菌感染的临床分布及耐药状况。方法:回顾性分析2012年1月-2013年12月笔者所在医院检出的285株侵袭性真菌真菌的菌群分布及耐药性特点。结果:285株真菌中检出率最高的是白色假丝酵母菌219株,占76.84%。5种假丝酵母菌对5-氟胞嘧啶和两性霉素B的敏感性最高分别为95.4%和76.9%以上,白色假丝酵母菌对5-氟胞嘧啶、两性霉素B、伏立康唑以及氟康唑的敏感性较高达到94.1%以上,但对伊曲康唑的敏感率仅为46.1%,光滑假丝酵母菌和克柔假丝酵母菌对伊曲康唑的耐药率均为100%。近平滑假丝酵母菌和热带假丝酵母菌对氟康唑的耐药率分别为68.2%和33.3%。结论:进行真菌培养和药敏试验对指导临床合理使用抗真菌药物十分重要。Objective：To understand the clinical distribution and drug resistance status of invasive fungal infections.Method：To retrospective analysis the flora distribution and drug resistance characteristic of 285 strains of invasive fungi in our hospital from January 2012 to December 2013.Result：The highest rate of was Candida albicans strains in 285 strains of fungi which was 219 strains,accounted for 76.84%.The most sensitive of 5 kinds of Candida on 5-fluorocytosine and amphotericin B were above 95.4%and 76.9%,sensitivity of Candida albicans to 5-flucytosine,Amphotericin B and Fluconazole,Voriconazole reached over 94.1%,but the sensitivity rate to itraconazole was only 46.1%,Candida glabrata and Candida krusei resistant to Itraconazole rate was 100%.The resistances of Nearly smooth Candida albicans and Candida tropicalis to Fluconazole were respectively 68.2%and 33.3%.Conclusion：Fungal culture and drug sensitivity test are important for rational use of antifungal drugs,and they can guide the clinical significant.

关 键 词：侵袭性真菌感染 药敏试验 耐药分析 

分 类 号：R446.5[医药卫生—诊断学]