西地那非治疗新生儿持续肺动脉高压25例临床观察  

Effect of sildenafil in treatment of persistent pulmonary hypertension of new born:a clinical observation of 25 cases

作　　者：刘洵洵 王佐[1] 范莉莉[1] 徐济宝 吕雪芬[1] 

机构地区：[1]安徽省芜湖市第一人民医院新生儿科,241000

出　　处：《淮海医药》2014年第4期341-343,共3页Journal of Huaihai Medicine

摘　　要：目的：观察西地那非治疗新生儿持续肺动脉高压的疗效。方法本资料45例新生儿持续肺动脉高压患儿，其中，观察组25例，为2012年6月-2013年5月入住患者，对照组20例，为2011年6月-2012年5月入住患者；对照组采取常规治疗；观察组在常规治疗的基础上加用西地那非1～1．5 mg/kg，q 6 h，鼻饲，疗程1～2 d。比较2组治疗后肺动脉压（ PAH）、吸氧浓度分数（ FiO2）、动脉血氧分压（ PaO2）变化及不良反应情况，同时比较2组呼吸机使用时间、住院天数。结果治疗后观察组比对照组临床症状及肺动脉压明显改善，且未出现严重不良反应。结论西地那非治疗新生儿持续肺动脉高压，疗效显著，方法简单易行，无不良反应。Objective To observe the effect of sildenafil in the treatment of persistent pulmonary hypertension of new born （ PPHN） .Methods 45 cases with PPHN were selected and divided into two groups .The test group included 25 cases of pa-tients admitted between June 1, 2012 and May 31,2013.The control group had 20 cases with patients from June 1,2011 to May 31,2012.The control group was treated with conventional therapy but the test group was aided by sildenafil on the basis of conventional therapy .Comparison between the two groups was conducted in terms of the post -treatment changes of PAH , FiO2 and PaO2 ,adverse reactions as well as the time of using respirator and the time of hospitalization .Results Compared with the control group ,clinical symptoms and PAH had been ameliorated better in the test group .No severe adverse reactions occurred in the two groups .Conclusion Sildenafil in the treatment of PPHN has apparent clinical effect .It can be administered easily with no adverse reaction .It is worth to be promoted in clinical treatment .

关 键 词：西地那非 高血压 肺性 新生儿 

分 类 号：R722[医药卫生—儿科]