调节性B细胞在风湿性疾病中的研究进展  

Research Advancement of Regulatory B Cells in Rheumatic Disease

作　　者：张笑梅[1] 王晓非[1] 

机构地区：[1]中国医科大学附属盛京医院风湿免疫科,沈阳110022

出　　处：《医学综述》2014年第10期1735-1737,共3页Medical Recapitulate

基　　金：辽宁省医学高峰工程项目(2010696)

摘　　要：近些年,调节性B细胞的免疫调节作用被高度关注。它们通过分泌白细胞介素10、转化生长因子β等抑制性介质或细胞接触等机制发挥下调免疫反应的作用,与肿瘤、感染、自身免疫性疾病等关系密切。风湿性疾病为一组累及全身结缔组织的自身免疫性疾病,过度免疫为风湿性疾病发生、发展的重要原因之一。调节性B细胞在风湿性疾病发生、发展中起着免疫抑制作用,在未来风湿性疾病治疗中有着广阔前景。In recent years,the immune regulatory function of regulatory B cell is attracting considerable attention.They can negatively regulate immune response by the mechanism of producing negative regulatory cytokines like IL-10 and TGF-β,or by cell-cell connection.Regulatory B cell is thought to be related to tumor,infection as well as some autoimmune diseasese.Rheumatic disease is a kind of autoimmune disease that involves systemic connective tissue.llyperimmunization is considered to be a major cause of the occurrence and development of rheumatic disease.Regulatory B cell play an immunosuppressive role in rheumatic disease and holds extraordinary promise in future therapy of rheumatic disease.

关 键 词：调节性B细胞 自身免疫性疾病 风湿性疾病 免疫调节 

分 类 号：R593.2[医药卫生—内科学]