钙离子/钙调蛋白依赖性蛋白激酶Ⅱ在心力衰竭与触发性心律失常中的信号转导作用  

The Signal Transduction Role of Ca^(2+)/Calmodulin Dependent Protein KinaseⅡin Heart Failure and Triggered Arrhythmias

作　　者：刘宇[1] 刘如秀[1] 

机构地区：[1]中国中医科学院广安门医院心内科,北京100053

出　　处：《医学综述》2014年第10期1750-1752,共3页Medical Recapitulate

基　　金：国家自然科学基金(81173447)

摘　　要：心力衰竭的心肌细胞可发生组织重构和电重构,尤其是细胞内钙离子循环出现障碍时,引起心脏电-机械活动异常,这也是其心律失常产生的主要原因。近年来研究表明,钙离子/钙调蛋白依赖性蛋白激酶Ⅱ通过调节钙循环的各个环节,在心肌肥大和凋亡所致心电重构和心力衰竭的发生、发展中起着关键的信号转导作用,该文将近年来的研究进展扼要概述。In heart failure,tissue remodeling and electrical remodeling of cardiac muscle cells may happen,especially when there is intracellular Ca^2 ＋ circulation obstacle,unusual cardiac electrical-mechanical activity is caused,which is the main cause of arrhythmia.In recent years,studies have shown that Ca^2 ＋ /calmodulin dependent protein kinase Ⅱ play a key signal transduction role in electrical remodeling and heart failure by regulating each link of calcium circulation in myocardial hypertrophy and apoptosis,and here is to make a review of the research progress in recent years.

关 键 词：钙离子钙调蛋白依赖性蛋白激酶Ⅱ 心力衰竭 心电重构 

分 类 号：R541.6[医药卫生—心血管疾病] R541.7[医药卫生—内科学]