脂联素与血管内皮功能修复的研究进展  

Research Progress of Adiponectin and Vascular Endothelial Function Repair

作　　者：李智慧[1,2] 杨长春[1] 韩盈[1] 

机构地区：[1]中国人民武装警察部队总医院南楼一科,北京100039 [2]新乡医学院,河南新乡453003

出　　处：《医学综述》2014年第10期1756-1759,共4页Medical Recapitulate

摘　　要：内皮功能紊乱是动脉硬化和糖尿病血管并发症的始动和关键环节。脂联素作为一种脂肪细胞因子,与内皮依赖性血管舒张功能呈独立正相关,其通过多重途径上调内皮细胞一氧化氮合酶活性,增加一氧化氮生成,抑制内皮细胞氧化应激反应,降低细胞损伤程度,阻断内皮细胞炎症,减轻血管内皮损伤。因此,脂联素可能是联系代谢综合征和心血管疾病的枢纽,可能为修复血管内皮功能开辟新的领域,进而预防或延缓心血管疾病的进展。Endothelial dysfunction is a starting and key link in atherosclerosis and vascular complications of diabetes. Adiponectin is an adipokine, and is independently positively correlated with endothelium dependent vasodilation, which upregulates the activity of endothelial nitric oxide synthase, increases production of nitric oxide, inhibits of endothelial cells from oxidative stress response, reduces the degree of cells damage, blocks the signal transduction of endothelial cells inflammation, and reduces endothelial damage through multiple signal transduction pathways. Therefore, adiponectin may be a link of the metabolic syndrome and cardiovascular disease, and may open up new areas for repair of vascular endothelial function, and prevent or delay the progression of cardiovascular disease.

关 键 词：脂联素 血管内皮 功能修复 

分 类 号：R54[医药卫生—心血管疾病]