缺血状态下心肌代谢变化的研究概况  

Research Overview of Myocardial Metabolic Changes under Ischemia Condition

作　　者：王俊梅[1,2] 李伟 颜璐璐 马晓慧 马英丽[1] 

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]天士力研究院药理毒理研究所,天津300410

出　　处：《医学综述》2014年第11期1963-1965,共3页Medical Recapitulate

摘　　要：心肌缺血是临床上常见的病症之一,多由冠状动脉粥样硬化所引起,其发病率日趋升高,严重威胁着人类健康。心肌缺血时,由于供氧或供血不足,必然引起心肌代谢紊乱,最终导致心肌细胞不同程度的损伤。该文主要从心肌缺血状态下能量代谢、氨基酸代谢、脂代谢、乳酸代谢等方面的变化以及代谢组学在该领域的应用作一综述,旨在阐述心肌缺血引起的相关代谢变化,为心肌缺血疾病的深入研究提供参考依据。Myocardial ischemia is one of the common diseases in clinical, which is generally caused by coronary atherosclerosis. With the increasing incidence, it has become a serious threat to human health. Myocardial ischemia,with a lack of oxygen or blood, inevitably causes myocardial metabolic disorders and leads to different degrees of damage of myocardial cells. Here is to make a review of energy metabolism, amino acid metabolism,lipid metabolism and lactate metabolism and the application of metabonomics technology in the field,with the aims to elaborate the changes caused by myocardial ischemia, and provide references for further study of myocardial ischemia.

关 键 词：心肌缺血 心肌代谢 代谢组学 

分 类 号：R541.4[医药卫生—心血管疾病]