6-烷氧基-7-甲基-4-羟基-3-喹啉羧酸乙酯的合成和抗球虫活性研究  

Synthesis and anticoccidial activities of ethyl 6-alkoxyl-4-hydroxy-7-methyl-3-quinolone-carboxylates

作　　者：陈广民 徐箭[2] 翁亚彪[3] 王玉良[2] 

机构地区：[1]广州巨元生化有限公司,广东广州510663 [2]四川大学化学学院,四川成都610064 [3]华南农业大学动物科学院,广东广州510642

出　　处：《化学研究与应用》2014年第6期900-904,共5页Chemical Research and Application

摘　　要：本文设计和合成了4个新的6-烷氧基-7-甲基-4-羟基-3-喹啉羧酸乙酯类化合物,新化合物的结构经1H NMR,IR,HR-MS所证实。依据ACI方法(抗球虫指数)对其进行了抗球虫活性试验,结果表明:化合物5a、5d在27mg·kg-1时对于柔嫩艾美耳球虫具有一定的抗球虫活性。Four new compounds,6-alkoxyl-4-hydroxy-7-methyl-3-quinoline-carboxylates,were synthesized. Their structures were i-dentified by 1 HNMR,HR-MS,and IR spectra. The anticoccidial activity of new compounds were tested according to the ACI（ the an-ticoccidial index）method. The results showed that compounds 5a and 5d exhibited good anticoccidial activity against Eimeria tenella in the chicken diet with a dose of 27 mg·kg^-1 .

关 键 词：6-烷氧基-7-甲基-4-羟基-3-喹啉羧酸乙酯 抗球虫活性 ACI方法 

分 类 号：O626.323[理学—有机化学]