大鼠甲醇中毒后视网膜电图振荡电位的变化  

Changes of Oscillatory Potentials of Electroretinogram after Methanol Intoxication in Rats

作　　者：刘冬梅[1,2] 周姝[2,3] 陈捷敏[2] 彭书雅[1,2] 夏文涛[2] 

机构地区：[1]苏州大学医学部法医学系,江苏苏州215123 [2]司法部司法鉴定科学技术研究所上海市法医学重点实验室,上海200063 [3]复旦大学上海医学院法医学系,上海200032

出　　处：《法医学杂志》2014年第3期178-180,共3页Journal of Forensic Medicine

基　　金：上海市法医学重点实验室资助项目(14DZ2270800);司法部司法鉴定科学技术研究所自然基金资助:GY2013Z-1)

摘　　要：目的研究大鼠甲醇中毒后视网膜电图(electroretinogram,ERG)振荡电位(oscillatory potentials,OPs)的变化特点。方法建立对照组及甲醇中毒3 d组、中毒7 d组的SD大鼠模型,在相应时间点于暗室内进行ERG检测,记录OPs波形特点。结果相对于对照组,中毒3d组和中毒7d组的总振幅均下降了约50%,时程分别延长约16%和61%。结论大鼠甲醇中毒后,ERG的OPs呈现时程延长、总振幅下降特点。Objective To study the characters of oscillatory potentials （OPs） of electroretinogram （ERG） after methanol intoxication in rats. Method The SD rat models of methanol intoxication were established and divided into control group, 3day intoxication group, 7day intoxication group. The changes of OPs of ERG were recorded in a dark room. Results The total amplitudes of 3day and 7day intoxication groups decreased approximately 50% compared with that of the control group, while the schedule delayed approximately 16% and 61%, respectively. Conclusion The characters of methanol intoxication in rats included delay in schedule and decline in the total amplitude of OPs.

关 键 词：法医学 中毒 甲醇 视网膜电图 振荡电位 大鼠 

分 类 号：DF795.1[医药卫生—法医学]