球形扩散控制体系中药物释放的建模及优化  

Modeling and Optimization of Drug Release from Diffusion-Controlled Spherical Devices

作　　者：黄建敏 王文俊[1] 李伯耿[1] 朱世平[2] 

机构地区：[1]化学工程联合国家重点实验室(浙江大学),浙江大学化学工程与生物工程学系,浙江杭州310027 [2]加拿大麦克马斯特大学化工系,汉密尔顿L4S4L7

出　　处：《高校化学工程学报》2014年第3期618-625,共8页Journal of Chemical Engineering of Chinese Universities

基　　金：国家自然科学基金项目(21074116,20936006);浙江省重大科技专项国际科技合作项目(2008C14087);化学工程联合国家重点实验室开放课题SKL-ChE-08D02

摘　　要：针对球形扩散控制体系中的药物释放,通过建立数学模型,借鉴反问题求解思路,利用混合Newton-Tikhonov正则化方法,优化体系中初始药物浓度分布以及扩散系数分布,实现不同的目标药物释放。在固定扩散系数条件下,优化了实现拟恒速、速率线性降低及先增后恒速的非线性释放目标的初始药物浓度分布;还优化了不同初始药物浓度分布条件下的体系扩散系数分布,以期达到拟恒速释放。研究表明:通过优化球形基质体系中药物的初始浓度分布或扩散系数分布,体系的药物释放可达到释放的目标要求;通过简单的外层无/少药物负载的初始浓度设计,优化扩散系数的体系可有效解决"突释"问题。This work presents an optimization approach for achieving desirable drug release from diffusion-controlled spherical devices. A mathematical model was established for description of drug release in these devices. Initial drug concentration and diffusivity profiles were optimized using a mixed Newton-Tikhonov regularization method to study various targeted release performances. Pseudo constant release, linear decrease release and linear increase followed by a constant release profiles were achieved under constant diffusivity with optimized initial drug concentration distributions, while the diffusivity profiles in devices with different initial concentration profiles were optimized to establish a pseudo constant release profile. The results show that the targeted drug release in the spherical devices can be fulfilled by optimizing the initial drug concentration or diffusivity profile. Moreover, burst effects could be minimized by maintaining low or no drug at the outer layer of the spherical devices with optimized diffusivity profiles.

关 键 词：球形扩散控制体系 药物释放 优化 建模 

分 类 号：TQ450.14[化学工程—农药化工]