马钱子生物碱微囊的制备及评价  

Preparation and Evaluation of Microcapsules of Strychnos Alkaloids

作　　者：潘洁文 马东升[1] 张立国[1] 倪力军[1] 

机构地区：[1]华东理工大学化学与分子工程学院,上海200237

出　　处：《华东理工大学学报（自然科学版）》2014年第3期296-301,共6页Journal of East China University of Science and Technology

基　　金：上海市科技支撑项目(13401901100)

摘　　要：为降低马钱子生物碱的释放速率,采用乳化-溶剂扩散法制备马钱子生物碱微囊,以载药量、包封率、外观形态等为考核指标,通过正交试验对制备工艺条件进行优化并考察其体外溶出性能。结果表明:在优化的工艺条件(囊芯和囊材质量比为1∶2,囊材质量浓度0.135g/mL,乳化剂体积分数2%,有机相和水相体积比为1∶5)下3次平行制得微囊的包封率和载药量的平均值分别为53.99%和18.25%;微囊外观光滑圆整,流动性好且粒径分布较窄;微囊中的马钱子碱与士的宁在人工胃液中具有良好的体外缓释效果。In order to reduce the release rate of Strychnos alk was applied to prepare microcapsules of Strychnos alkaloids. Ort optimize the preparation conditions using drug loading（DL）, enc of the microcapsules as the evaluation indexes. The in vitro studied. The results indicate that the optimal preparation conditi aloids, emulsion-solvent diffusion method hogonal experiment design was applied to apsulation efficiency（EE） and appearance release of Strychnos alkaloids was also ons of microcapsules are as follows, mass ratio of strychnine alkaloids to capsule material 1：2, mass concentration of capsule material 0. 135 g/mL, emulsifier＇s volume fraction 2%, and volume ratio of the organic phase to the aqueous phase 1：5. The average encapsulation efficiency and drug loading capability of Strychnos alkaloids in the microcapsules prepared by three times parallel experiments are 53. 99% and 18. 25%, respectively. The microcapsules have good sphericity, fluidity and uniform size. The Strychnos alkaloids in the microcapsules slowly dissolve in artificial gastric juice.

关 键 词：微囊 乳化-溶剂扩散法 生物碱 体外溶出 

分 类 号：R917[医药卫生—药物分析学]