复方卡尼汀治疗慢性病毒性肝炎  

Compound carnitine in treating chronic viral hepatitis

作　　者：杨金龙[1] 夏子禹 游龙英 郑水根[1] 吕萍[1] 张小青[1] 

机构地区：[1]上海市第八人民医院传染病科,上海200233

出　　处：《中国新药与临床杂志》2001年第2期125-126,共2页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :评估复方卡尼汀治疗慢性病毒性肝炎的作用。方法 :91例慢性病毒性肝炎病人分为 2组。对照组 30例 (男性 2 0例 ,女性 10例 ,年龄 4 1a±s 17a) ,给予甘草酸单铵 80mL加入 10 %葡萄糖注射液 50 0mL中iv ,gtt ,qd ,疗程 30d。治疗组61例 (男性 4 9例 ,女性 12例 ,年龄 4 0a± 13a) ,在甘草酸单铵治疗基础上 ,给予复方卡尼汀 2支加入10 %葡萄糖注射液 50 0mL中iv ,gtt ,qd ,疗程 30d。结果 :治疗组对改善病人乏力、纳差、降低ALT的总有效率分别为 93% ,10 0 % ,92 % ,均明显优于对照组 75% ,84 % ,70 % (P <0 .0 5)。对 2组部分病人治疗 6mo时的随访表明治疗组的ALT复常率为83% ,明显高于对照组 54% (P <0 .0 5) ,无明显不良反应。结论AIM: To observe the clinical effect of compound carnitine in treating chronic viral hepatitis. METHODS: Ninety one patients with chronic viral hepatitis were randomly divided into 2 groups. Control group of 30 patients (M 20,F 10; age 41 a± s 17 a) received compound glycynhizin 80 mL in 10% glucose injection 500 mL, iv, gtt, qd for 30 d. The treatment group of 61 patients(M 49,F 12; age 40 a±13 a) received compound carnitine 2 ampules. in 10% glucose injection 500 mL, iv, gtt, qd for 30 d, besides the compound glycyrrhizin therapy. RESULTS: The total response rate of improving the patients' fatigue, anorexia and normalization of ALT in the treatment group were 93%, 100% and 92% respectively, which was more excellent than that (75%, 84% and 70% respectively) in the control group ( P <0.05). At the end of 6 mo treatment, the rate of the normalization of ALT in the treatment group was 83%, which was much higher than that (54%) in the control group ( P <0.05), according to the statistics of the partial patients in both groups. No obvious adverse reaction was observed.CONCLUSION: Compound carnitine is an effective drug in treating chronic viral hepatitis.

关 键 词：慢性病毒性肝炎 药物疗法 复方卡尼汀 治疗 

分 类 号：R512.605[医药卫生—内科学] R977.9[医药卫生—临床医学]