非诺特罗及异丙托溴铵单用或联用吸入治疗小儿哮喘发作  

Fenoterol and ipratropium bromide inhalation alone or combined in treatment of childhood acute paroxysm of asthma

作　　者：刘群[1] 张家伟[1] 林洁[1] 张静[1] 

机构地区：[1]成都市第二人民医院,四川成都610017

出　　处：《中国新药与临床杂志》2001年第2期135-136,共2页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :观察非诺特罗、异丙托溴铵单用及联合用药治疗小儿哮喘急性发作的疗效。方法 :哮喘急性发作病儿 95例分 3组 :A组 30例 ,给 0 .5%非诺特罗剂量 ,年龄为 2～ 6a ,0 .1mL ,6～ 14a ,0 .2mL ;B组 30例 ,给 0 .0 2 5%异丙托溴铵剂量 ,年龄为 2～ 6a ,0 .5mL ,6～ 14a ,1mL ;C组 35例 ,给非诺特罗 +异丙托溴铵 ,2药剂量同前。 3组药物均加氯化钠注射液稀释至 3mL雾化吸入 ,tid× 2～ 5d。结果 :3组显效率依次为 63 % ,60 % ,86%。A组与B组显效率P >0 .0 5,分别与C组比较显效率P<0 .0 5。 3组均未见不良反应。结论 :非诺特罗、异丙托溴铵治疗小儿哮喘急性发作 ,单独用药疗效相似 。AIM:To observe the effect of fenoterol and ipratropium bromide alone or combined in the treatment of childhood acute paroxysm of asthma. METHODS: Ninty five children with acute paroxysm of asthma were divided into 3 groups:group A of 30 children (age 6 a ±s 4 a) received 0.5% fenoterol 2 6 a 0.1 mL, 6 14 a 0.2 mL; group B of 30 children (age 7 a±3 a) received 0.025% ipratropium bromide 2 6 a 0.5 mL, 6 14 a 1 mL; group C of 35 children (age 6 a±3 a) received the same dosage of fenoterol+ipratropium bromide as the other two groups. The drug in 3 groups diluted with 0.9% sodium chloride to 3 mL, aerosol inhalation spray inhalation, tid, for 2 5 d. RESULTS: The obvious effective rate 63% in group A was similar to that of group B 60% ( P >0.05), but was lower than that of group C 86% ( P <0.05). The adverse reaction wasn't found in 3 groups. CONCLUSION: In treating the childhood acute paroxysm of asthma, the effect of fenoterol is similor with ipratropium bromide, but the combination drug gives a better therapy than either drug alone.

关 键 词：哮喘 药物疗法 非诺特罗 异丙托溴铵 吸入疗法 儿童 

分 类 号：R725.622.5[医药卫生—儿科] R974.3[医药卫生—临床医学]