生脉注射液对阻塞性黄疸术后炎症介质及肾功能作用的研究  

CLINICAL STUDY OF SHENGMAI INJECTION ON INFLAMMATORY MEDIATOR AND RENAL INJURY OF POST OPERATIVE PATIENTS WITH OBSTRUCTIVE JAUNDICE

作　　者：彭兵 雷文章[1] 吴言涛[1] 刘小菁[1] 强欧[1] 

机构地区：[1]华西医科大学附一院外科,四川成都610041

出　　处：《华西药学杂志》2001年第1期64-65,共2页West China Journal of Pharmaceutical Sciences

基　　金：卫生部科研基金资助! (98-1-2 15 )

摘　　要：目的 :观察生脉注射液对阻塞性黄疸 (阻黄 )术后炎症介质及肾功能的作用。方法 :阻黄及非黄疸的肝胆外科患者分成三组 ,术后给予一般治疗阻黄 (OJ)组、非黄疸 (NON OJ)组及生脉注射液治疗阻黄组。动态观察血浆炎症介质内毒素 (LPs)、肿瘤坏死因子 (TNF α)、白细胞介素 6 ,8(IL 6 ,IL 8)、内皮素 (ET)以及肾脏功能指标尿转铁蛋白 (TFR)、尿白蛋白 (ALB)及尿视黄醇 (RBP)的变化。结果 :生脉注射液治疗组术后 7天与术后 1天相比 ,LPs、IL 6、IL 8、ET、TNF α、TFR、RBP、ALB明显下降 (P <0 0 5〉 ,且低于或接近术前水平 ,黄疸对照组在术后 7天与术后 1天相比无显著差异 (P >0 0 5 )。结论 :生脉注射液对阻黄患者术后LPs有拮抗作用 ,同时降低其它炎症介质水平 ,另外还具有保护肾脏功能的作用。OBJECTIVE:To investigate the effect of Shengmai injection on inflammatory mediator and renal injury in obstructive jaundice METHODS:The patients with obstructive jaundice were randomly divided into 2 groups 15 cases of non jaundiced patients as another control group according to preoperative arrangement The plasma ET, LPs, TNF а, IL-6, IL 8 and urine RBP, TFR, ALB were measured pre and post operative 1, 4, 7 days RESULTS:LPs , TNF а, IL 6, IL 8, ET, RBP, TFR and ALB level of Shengmai injection group during post operative 7 day were obviously lowered as compared with the same group during post operative 1 day( P <0 05) CONCLUSION:post operative uses of Shengmai injection might effectively decrease the post operative level of plasma LPs, ET, TNF α and IL 6,IL 8 At the mean time, Shengmai injection may protect renal function by inhibiting inflammatory mediator and improving blood dynamics

关 键 词：生脉注射液 炎症介质 阻塞性黄疸 肾功能 

分 类 号：R259.750.5[医药卫生—中西医结合] R654.4[医药卫生—中医内科学]