不稳定型心绞痛患者血小板活化状态的临床研究  

PLATELET ACTIVATION IN PATIENTS WITH UNSTABLE ANGINA PECTORIS

作　　者：朱建健[1] 高海青[2] 张志勉[2] 

机构地区：[1]北京大学第一医院心内科 [2]山东大学齐鲁医院干部保健科

出　　处：《山东医科大学学报》2001年第1期16-17,20,共3页Acta Academiae Medicinae Shandong

摘　　要：目的 :考察不稳定心绞痛 (UAP)患者体内血小板活化状态 ,探讨冠脉病变严重程度与血小板活化程度的关系。方法 :UAP组 55例 ,稳定心绞痛 (SAP)组 32例 ,均服用阿斯匹林 75mg/d ,对照组 4 0例。采用流式细胞术测定活化血小板的膜蛋白CD63、CD62P、TSP的表达率。观察行冠脉造影术 4 2例UAP患者 ,比较单支病变组、双支病变组和 3支病变组血小板膜蛋白表达率的差异。结果 :UAP组中 3种膜蛋白的表达率均显著高于SAP组和对照组 ,男女之间无显著性差异 ,双支组和 3支组显著高于单支组。结论 :UAP患者存在高度的血小板活化状态 ,随冠脉病变严重程度增加而增加 ,小剂量阿斯匹林治疗的UAP患者仍有较高的血小板活化状态。Objective:To assess the platelet activation state in patients with unstable angina pectoris(UAP) and to investigate the relationship between the severity of coronary artery stenosis and platelet activation. Methods:CD63,CD62P and thrombospondin were detected using flow cytometry in 55 patients with UAP,32 with stable angina pectoris(SAP)(both given aspirin 75 mg/d) and 40 healthy controls.42 patients with UAP underwent elective coronary arteriography.There were 10 patients with single vessel disease,21 with double vessel disease and 11 with three vessel disease.Results:The three parameters in UAP group were significantly higher than in SAP and controls.There was no significant difference between male and female.Groups of double and three vessel disease had significantly increased CD63 and thrombospondin expression comparing with single vessel disease.Conclusion:There is elevated platelet activation in patients with UAP.Platelet activation raises with the increase of severity of coronary artery disease.Low dose oral aspirin(75mg/d) can not completely inhibit platelet activation in patients with UAP.

关 键 词：不稳定型心绞痛 血小板活化 CD63 P选择素 凝血酶敏感蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]