正交试验法优化白金胶囊中白芍的提取工艺  

Optimization of Extraction Process for Radix Paeoniae Alba in Baijin Capsule by Orthogonal Experiment

作　　者：张慧[1] 付京[1] 陈杨[1] 许梦洁[1] 豆浩然 杨博迪 倪健[1] 

机构地区：[1]北京中医药大学中药学院,北京100102

出　　处：《中国中医药信息杂志》2014年第7期64-66,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81173563);国家科技重大专项-重大新药创制(2012ZX09103201-026);北京中医药大学复方中药制药创新团队(2011-CXTD-13)

摘　　要：目的采用正交试验法优选白金胶囊中白芍的提取工艺。方法采用正交设计,以白芍中芍药苷及白芍总苷的提取率作为评价指标,考察溶剂用量、提取时间和提取次数对提取结果的影响,确定最佳提取工艺。结果白芍的最佳提取工艺为:14倍量70%乙醇,回流提取3次,每次1.5 h。结论本试验方法简单稳定,对白金胶囊的生产工艺具有一定的指导和参考意义。Objective To optimize the extraction process of Radix Paeoniae Alba in Baijin Capsule by orthogonal experiment.Methods The study employed the extraction rate of paeoniflorin and total glucosides of paeony as evaluation indexes. The orthogonal design was used to investigate effects of solvent volume, extraction time and extraction frequency on extraction results.Results The optimal extracting condition was extracted 3 times, with 14 fold 70% alcohol, 1.5 h for each time. Conclusion The method is simple and steady, which will provide instruction and reference to the production of Baijin Capsule.

关 键 词：正交试验法 白芍 白金胶囊 提取工艺 

分 类 号：R283.5[医药卫生—中药学]