海龙体外抗肿瘤活性研究  

Study on Anticancer Activity of Syngnathus in Vitro

作　　者：李士敏[1] 吴筱丹[1] 曾苏[1] 栾连军[1] 邵青[1] 

机构地区：[1]浙江大学药物制剂研究所,浙江杭州310031

出　　处：《中国中药杂志》2001年第3期198-200,共3页China Journal of Chinese Materia Medica

基　　金：浙江省自然科学基金课题!(3 95 13 1)

摘　　要：目的 :筛选不同品种海龙的体外抗肿瘤活性部位。方法 :采用MTT法观察海龙的各种提取物对多种人癌细胞株生长的影响。结果 :尖海龙的 95 %乙醇提取物对KB细胞的生长具有抑制作用 ,并呈量效关系 ;粗吻海龙的脂溶性非皂化物具有不同程度的抑制人癌细胞株KB ,Hela ,Bcap37,K5 6 2 ,PAA细胞的作用 ,并有明显的量效关系 ;拟海龙的各提取物未见有明显的抑制肿瘤细胞生长的作用。结论Objective: To study the anticancer activity of Syngnathus in vitro. Method: Observing the influence of different extracts from Syngnathus on growth of different cancer cell strains by MTT method. Result: It has been found out that the fat-soluble nonsaponified extract from Temminck et Schlegel and the alcoholic extract from Syngnathus acus have cytotoxic activities.The nonsaponified extract from Temminck et Schlegel can inhibit the grouth of cancer cell strains KB,Hela,PAA,K562,and Bcap37,and the alcoholic extract from Syngnathus acus can inhibit the growth of cancer cell strin KB,But Bloch shows no apparent anticancer activity. Conclusion: Syngnathus has promising prospects as an anticancer Chinese medicine.

关 键 词：拟海龙 尖海龙 粗吻海龙 体外抗肿瘤 MTT法 

分 类 号：R285.5[医药卫生—中药学]