高温负荷对空间工作记忆的影响——功能磁共振研究  

The effect of hyperthermia on spatial working memory：an fMRI study

作　　者：姜庆军[1] 杨晓[1] 刘锴[1] 李勃[1] 李理[1] 李敏[1] 钱绍文[1] 马力飞 孙钢[1] 

机构地区：[1]济南军区总医院医学影像科,山东济南250031 [2]北京佳恒创新科技有限公司

出　　处：《实用放射学杂志》2014年第6期897-900,共4页Journal of Practical Radiology

摘　　要：目的：采用功能磁共振（fMRI）方法探讨高温暴露后被试者在完成空间记忆任务时大脑各区域的变化。方法28例健康男性青年右利手志愿者，分别在常温和高温下进行空间记忆任务行为学测试和功能磁共振实验。对比高温组和实验组二者在脑区激活范围和程度的差异。结果常温组和高温组都引起额叶、顶叶、枕叶及岛叶的激活；常温下，空间记忆任务为右侧大脑加工优势（Li=0.051），高温下，这种右侧加工优势明显增强（Li=0.103），双侧额中回及右侧顶叶的激活较常温时显著增强。结论高温负荷对双侧额中回及右侧顶叶等工作记忆所涉及的脑区有明显影响，加重了工作记忆中的右半球偏侧化优势。Objective To explore the changes of different brain regions of the human beings during completion of spatial working memory tasks under hyperthermia condition with functional magnetic yesonance.Methods Twenty-eight right-handed healthy young male volunteers were divided into control group and hyperthermia group randomly,and working memory task using block design was performed during behavioral test and fMRI scanning on both conditions.Activation intensity and location of different brain areas were compared in control and hyperthermia group.Results The activations of frontal,parietal,occipital and insular lobe were seen in both of the control group and the hyperthermia group.Right lateralization was shown in control group during spatial working memory （Li=0.05 1）.While,in hyperthermia group the effect of the right lateralization significantly was enhanced （Li=0.103）. Moreover,activation of bilateral middle frontal gyrus and right parietal lobe were significantly enhanced.Conclusion It is found for the first time that the hyperthermia could affect bilateral middle frontal gyrus and right parietal lobe,and enhance the effect of right lateralization in the spatial working memory task.

关 键 词：高温 功能磁共振 空间工作记忆 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.81[医药卫生—诊断学]