二级镀铜铂金微弹簧圈栓塞兔外周动脉的实验研究  

Experimental study of embolization of rabbits’peripheral arteries using secondary level copper plated platinum coils

作　　者：姜华[1] 濮进敏[1] 童玉云[1] 赵洁[1] 李琳[1] 李迎春[1] 王家平[1] 

机构地区：[1]昆明医科大学第二附属医院放射科,云南昆明650101

出　　处：《实用放射学杂志》2014年第6期1035-1039,共5页Journal of Practical Radiology

摘　　要：目的：探讨自制二级镀铜铂金微弹簧圈对兔血管栓塞的效果。方法选取新西兰大耳兔17只,采用自制的二级镀铜铂金微弹簧圈（实验组）经3 F 微导管释放,栓塞一侧锁骨下动脉或颈总动脉,然后再采用相同规格的二级铂金微弹簧圈（对照组）栓塞对侧锁骨下动脉或颈总动脉作栓塞对照分析。分别于栓塞前后不同时间测肝、肾功能及血清铜离子浓度；于栓塞术后不同时间观察血管闭塞情况和病理学改变。结果17只兔中15只完成栓塞实验。栓塞术后,血清铜离子术后2周内较术前升高,差异有显著性意义（P 〈0.05）,4周后与术前比较,差异无显著性意义（P〉0.05）；肝、肾功能2周后恢复至术前水平。栓塞后10 min、30 min,血管造影显示,2组间血管栓塞效果差异无统计学意义,3 d、1周、2周、4周、6周、12周时,实验组血管栓塞的效果均优于对照组,差异有统计学意义（P 值均〈0.01）。病理检查显示,实验组铜圈周围及其内部、血管远近端有大量的血栓。对照组弹簧圈周围仅见少量血栓,实验组各观察点的血栓形成情况均优于对照组（P 值均〈0.01）。但2组间炎性细胞浸润情况差异无统计学意义。结论二级镀铜铂金微弹簧栓塞效果肯定,其记忆性、柔韧性、可控性、释放性及稳定性优于二级铂金微弹簧圈。Objective To evaluate the embolic effect on rabbits arteries using self-made copper plated platinum coil.Methods 1 7 New Zealand Big Ear Rabbits were selected.Unilateral subclavian artery or carotid artery was embolized with self-made secondary level copper plated platinum micro-coils （experimental group）through 3F-catheter.Contralateral subclavian artery or carotid artery was also embolized using secondary level platinum micro-coils （control group）as a control.The level of serum copper ions and the liver and renal function were recorded during different intervals before and after embolization.The arteriography and the tissue histology were observed respectively during different intervals after the embolization.Results 1 5 of 1 7 rabbits were embolized successfully.After embolization,the level of serum copper ions increased in 2 weeks（P 〈0.05）.However,it returned to preoperative level after 4 weeks （P ＆gt;0.05）.The liver and renal function was similar to that of the preoperation after 2 weeks.After embolization,an-giography showed that vascular embolization effect between two groups was not significantly different at 10 min and 30 min;however,the embolization effect of experimental group was superior to that of control one （P 〈0.01）at 3 days and 1 week,2 weeks,4 weeks,6 weeks and 12 weeks.Pathological results showed that there were a lot of thromboses inside,outside and around the copper coil.Few thromboses appeared around platinum coil in control group.The thrombosis situation in experiment group was better than that in control one （P 〈0.01）.However,no significant difference in inflammatory cell infiltration between two groups was found. Conclusion Self-made secondary level copper plated platinum coil has good physical property,rememorability,flexibility and controllability.

关 键 词：金属铜 弹簧圈 栓塞动脉 家兔 统计学 

分 类 号：R332[医药卫生—人体生理学] R815[医药卫生—基础医学]