降钙素原指导下肠梗阻预防性抗生素应用的临床价值  

The clinical value of prophylactic antibiotics application under the guidance of procalcitonion in intestinal obstruction

作　　者：李绍堂[1] 蒋飞照[1] 朱恒梁[1] 阮小蛟[1] 郑晓风[1] 

机构地区：[1]温州医科大学附属第一医院普外科,浙江温州325015

出　　处：《温州医学院学报》2014年第5期367-369,共3页Journal of Wenzhou Medical College

基　　金：浙江省教育厅科研基金资助项目(Y201326738)

摘　　要：目的:探讨降钙素原指导下肠梗阻预防性抗生素应用的临床价值。方法:观察80例拟行非手术治疗的肠梗阻患者预防性抗生素应用的效果。80例患者在入院后第1、第3、第5天等隔日抽血检查降钙素原及血常规水平,至研究截点。其中40例患者(试验组)在降钙素原正常(<0.5 ng/mL)后停用抗生素。其余40例患者(对照组)依据传统标准停用抗生素。比较两组患者的治愈时间、感染相关并发症与抗生素应用天数。结果:两组患者治愈时间和感染并发症差异无统计学意义(P>0.05)。两组患者平均用药时间比较,试验组明显低于对照组,差异有统计学意义(P<0.01)。结论:降钙素原指导下肠梗阻预防性抗生素应用要优于传统标准抗生素应用。Objective： To explore the clinical value of prophylactic antibiotics application under the guid-ance of procalcitonion in intestinal obstruction.Methods： The results of prophylactic antibiotics application were observed and analyzed in 80 cases of non-surgical treatment of intestinal obstruction. Procalcitonion and blood routine were tested in all cases in 1, 3, 5 day after admission such as cut point for research. Forty patients （experimental group） stopped using antibiotics under the normal level of procalcitonion （〈0.5 ng/mL）. The rest of 40 patients （control group） stopped using antibiotics on the basis of traditional standard.Results： There was no signiifcant difference between two groups in cure time and infection complications （P〉0.05）; there was very sig-niifcant difference between two groups in average duration of antibiotics application, the experimental group was signiifcantly shorter than that of the control group （P〈0.01）.Conclusion： Prophylactic antibiotics application under the guidance of procalcitonion is superior to the traditional standard in intestinal obstruction patients.

关 键 词：降钙素原 肠梗阻 抗生素 预防性 应用 

分 类 号：R605[医药卫生—外科学]