p40、TTF-I、p63、CK5/6在肺腺癌和肺鳞癌中的表达及其意义  

Expressions and significance of p40,TTF-1,p63 and CK5/6 in lung adenocarcinoma and squamous carcinoma

作　　者：焦立卓 陈涵斌[1] 赵灵灵[1] 王玲[1] 林中民 陈霖[1] 陈国荣[1] 蔡国平[1] 

机构地区：[1]温州医科大学附属第一医院病理科,浙江温州325015

出　　处：《温州医学院学报》2014年第7期489-493,共5页Journal of Wenzhou Medical College

摘　　要：目的:探讨p40、TTF-1、p63和CK5/6在肺腺癌和肺鳞癌中的表达及其意义。方法:应用组织芯片技术结合免疫组织化学法,检测p40、TTF-1、p63和CK5/6在108例肺腺癌标本、66例肺鳞癌病理标本中的表达,分析其差异及临床病理意义。结果:①p40、p63、CK5/6、TTF-1在肺鳞癌中的阳性表达率分别为93.9%(62/66)、86.4%(57/66)、89.4%(59/66)、6.1%(4/62)。②p40、p63、CK5/6、TTF-1在肺腺癌中的阳性表达率分别为3.7(4/108)、22.2%(24/108)、24.1%(26/108)、95.4%(103/108)。③p40、p63、CK5/6在肺鳞癌中的特异度分别是96.3%、77.8%、75.9%,p40特异度高于p63、CK5/6(P<0.05)。④p40、p63、TTF-1与性别、病理类型、肿块大小、吸烟史有关(均P<0.05),与年龄、分化程度、淋巴结转移及TNM分期无关(均P>0.05)。⑤在低分化肺鳞癌中p40的阳性表达率(为89.3%)较p63(为78.6%)、CK5/6(为82.1%)高(均P<0.05)。结论:p40、TTF-1、p63和CK5/6在肺癌的诊断及鉴别中具有重要价值,p40对肺鳞癌的鉴别明显优于p63和CK5/6,p40在低分化肺鳞癌中具有较高的阳性表达率。性别、病理类型、肿块大小、吸烟史与p40、TTF-1、p63、CK5/6的表达有相关性。Objective： To explore the expression and differential significance of p40, TTF-1, p63 and CK5/6 in adenocareinama and squamous carcinoma of lung. Methods： Using the technology of tissue microar- ray and immunohistochemical method, the expression of p40, TTF-I, p63 and CK5/6 was detect in 108 cases specimens of lung adenocarcinoma and 66 cases specimens of lung squamous carcinoma and the difference and clinical pathological significance were analyzed. Results： （1）The positive expression rates of p40, p63, CK5/6, TTF-1 in lung squamous cell carcinoma were 93.9% （62/66）, 86.4% （57/66）, 89.4% （59/66） and 6.1% （4/62）, re- spectively. （2）The positive expression rates of p40, p63, CK5/6, TTF-1 in lung adenocarcinoma were 3.7 （4/108）, 22.2% （24/108）, 24.1% （26/108） and 95.4% （103/108）. （3）The specificity of p40, p63, CK5/6 for lung squarnous carcinoma was 96.3%, 77.8% and 75.9%, the specificity of p40 was higher than that of p63 and CK5/6 （P〈0.05）. （4）p40, p63 and TTF-1 had relevant with gender, pathological type, tumor size, history of smoking （P〈 0.05）, and had no relevant with age, the degree of differentiation, lymph node metastasis and TNM stages （P〉 0.05）. （5）The expression rate of p40 （89.3%） was higher than that of p63 （78.6%） and CK5/6 （82.1%） in poorly differentiated lung squamous carcinoma. Conclusion： p40, p63, CK5/6 and TTF-1 have a important value in the diagnosis and identify of lung cancer, p40 is obviously better than p63 and CK5/6 in the identification of lung squamous carci- nomas, and has higher expression rate in poorly differentiated squamous carcinoma of lung. Gender, pathological type. tumor size, history of smoking are relevant with the expression of p40, p63, TTF-1 and CK5/6.

关 键 词：P40 TTF-1 P63 CK5 6 免疫组织化学 肺肿瘤 鳞癌 腺癌 

分 类 号：R446[医药卫生—诊断学]