卵泡液中颗粒细胞FSHR的表达与体外受精-胚胎移植的相关研究  

Study of the Relationship between the Expression of FSH Receptor on Granulosa Cells and in Vitro Fertilization and Embryo Transfer(IVF-ET)

作　　者：杜婷[1] 任春娥[1] 韩海燕[1] 李建娟[1] 

机构地区：[1]潍坊医学院妇产科学教研室,山东潍坊261053

出　　处：《潍坊医学院学报》2014年第3期217-219,222,共4页Acta Academiae Medicinae Weifang

摘　　要：目的检测超促排卵治疗过程中卵泡液内颗粒细胞卵泡刺激素受体(FSHR)的表达水平,探讨FSHR表达与体外受精-胚胎移植(IVF-ET)中卵子质量和临床妊娠率的关系。方法随机选择在本中心行第一周期IVF-ET的患者35例。采卵日收集卵泡液中的颗粒细胞,检测FSHR的表达。结果卵子的卵裂率随颗粒细胞FSHR表达强度的增加而升高(r=0.681,P<0.05);卵子的受精率随颗粒细胞中FSHR表达的增加而升高(r=0.647,P<0.05);与临床妊娠组相比,非妊娠组患者卵泡液中颗粒细胞FSHR表达水平显著降低,差异有统计学意义(P<0.05),年龄、不孕年限、获卵率、卵子成熟度、优胚率差异无统计学意义。结论在IVF-ET中,卵泡液中颗粒细胞FSHR的表达水平将会影响卵子的质量,进而影响临床妊娠率。Objective To determine the expression of follicle stimulating hormone receptor （FSH-R）,and to study the relation-ship between FSHR expression with in vitro fertilization and embryo transfer （ IVF-ET） .Methods Thirty-five subjects receiving the first cycle of IVF-ET were enrolled from our center .The follicular fluid was collected ,and FSHR was measured in the day for ova collection .Results The fertilization rate with increasing content of FSHR increased （r=0.647,P〈0.05）;Compared with the pregnant group ,the non-pregnant group FSHR expression levels in patients with follicular granulosa cells was significantly lower ,and the difference was statistically significant （P〈0.05）.Conclusion The expression levels of FSHR affect ovas quality ,thereby affecting the pregnancy rate .

关 键 词：卵泡刺激素受体 卵泡液颗粒细胞 体外受精-胚胎移植 

分 类 号：R714.147[医药卫生—妇产科学]