中枢炎症机制在术后认知功能障碍中的作用  

The pathogenic role of central nervous system inflammation in postoperative cognitive dysfunction

作　　者：杨广慧[1] 鲁显福[1] 钱梅[1] 顾尔伟[1] 李元海[1] 

机构地区：[1]安徽医科大学第一附属医院麻醉科,合肥230022

出　　处：《国际麻醉学与复苏杂志》2014年第6期535-538,542,共5页International Journal of Anesthesiology and Resuscitation

基　　金：安徽省卫生厅医学科研重点项目（2010A011）;安徽省科技攻关计划项目（1301042204）

摘　　要：背景 术后认知功能障碍（postoperative cognitive dysfunction,POCD）是手术后出现的精神并发症,其发生机制不太清楚,近年来中枢炎症反应机制越来越受到重视. 目的 主要综述POCD的中枢炎症发病机制相关研究进展. 内容 POCD好发于老年患者合并代谢综合征、动脉粥样硬化及阿尔茨海默病等人群,而这些人群共有的特点是处于慢性炎症的预激状态;手术创伤虽非病因且是治愈外科疾病的关键,但因外科干预相关的“二次打击”伤害引起的中枢性神经免疫炎症级联放大机制、推进了POCD的发生. 趋向 控制围术期神经免疫炎症反应,有助于减少POCD.Background Postoperative cognitive dysfunction （POCD） is a serious mental issue after major surgeries, but its mechanism remains unclear. For the past few years, the mechanism of central nervous system inflammation in POCD has caused widespread attention. Objective To reviews the pathogenic role of central nervous system inflammation in POCD. Content Elderly patients with metabolic syndrome, atherosclerosis and Alzheimer＇s disease are more susceptible to POCD. The common feature in these POCD susceptible patients is chronic inflammation. Surgical trauma itself is not considered to be a disease, but surgical intervention （the ＂second hit＂ ） often lead to the development of systemic inflammatory state and exaggerated neuroimmuno- inflammatory response, and facilitate the incidence of POCD at the end. Trend The control of perioperative neuroimmuno- inflammatory response may reduce the incidence rate of POCD.

关 键 词：术后认知功能障碍 炎症 手术 老年人 

分 类 号：R614[医药卫生—麻醉学]