痰瘀同治高血压病的最佳干预时间和有效人群研究  

Clinical study on the optimal intervention time and target population of hypertension treatment with phlegm and blood stasis syndrome differentiation

作　　者：宇文亚[1] 韩学杰[1] 杨伟[1] 刘兴方[1] 刘大胜[1] 吕爱平[1] 

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《中华中医药杂志》2014年第6期1794-1796,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81202846);中国中医科学院自主选题(No.Z0221)~~

摘　　要：目的:研究痰瘀同治1、2级高血压病的最佳干预时间和有效人群。方法:将86例1、2级高血压病患者随机分为试验组38例,对照组48例。试验组采用中医药痰瘀同治,对照组服用降压西药,两组均治疗12周。分别于治疗前、治疗2、4、8、12周观察血压、症状积分、不良事件。结果:两组治疗2、4、8、12周改善血压总有效率比较均无统计学差异,试验组在治疗4、12周总有效率最高;两组治疗2、4、8、12周改善头晕、头如裹、身重困倦均无显著差异。两组在治疗12周,试验组改善心悸、胸闷、恶心优于对照组(P<0.05)。结论:本研究初步表明,痰瘀同治1、2级高血压病的最佳干预时间是12周,有效人群为心悸、胸闷、恶心的1、2级高血压病患者。Objective： To study the optimal intervention time and the target population of grade 1 and grade 2 hypertension treatment with phlegm and blood stasis syndrome differentiation. Methods： Eighty-six grade 1 and grade 2 hypertension patients were randomly divided into a treatment group （phlegm and blood stasis syndrome differentiation） and a control group （antihypertensive drugs）, with 38 and 48 in two groups. Each group was treated for 12 weeks. Hypertension, scores of symptoms, adverse event were observed before treatment and in 2, 4, 8, 12 weeks after treatment. Results： There was no significant difference in total effective rate scores between the treatment group and the control group in 2, 4, 8,12 weeks after treatment, but the total effective value in the treatment group was the highest in 4 and 12 weeks after treatment. There was no significant difference in improving the symptoms of dizziness, body weight between two groups in 2, 4, 8,12 weeks after treatment. There was no significant difference in improving symptoms of palpitation, chest stuffiness, nausea in 2, 4, 8 weeks after treatment, but there was a significant difference between two groups in 12 weeks after treatment （P〈0.05）. Conclusion： The optimal intervention time of phlegm and blood stasis was in 12 weeks after treatment, and the target population was grade 1 and grade 2 hypertension patients with the symptoms of palpitation, chest stuffiness and nausea.

关 键 词：痰瘀同治 高血压病 最佳干预时间 有效人群 

分 类 号：R259[医药卫生—中西医结合]