针药结合对绝经后骨质疏松症患者生殖内分泌激素及骨代谢的影响  

Effects of acupuncture combined with traditional Chinese medicine on procreateendocrine hormone and bone metabolism in postmenopausal osteoporosis

作　　者：张国山[1] 邱冉冉[2] 刘密[1] 常小荣[1] 刘文霞 

机构地区：[1]湖南中医药大学,长沙410007 [2]湖南中医药大学第一附属医院,长沙410007 [3]湖南省吉首市湘西自治州民族中医院,吉首416000

出　　处：《中华中医药杂志》2014年第6期1852-1854,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点基础研究发展计划(973计划)项目(No.2009CB522904);国家自然科学基金项目(No.81173326);长沙市科技计划重点项目(No.K1005020-31);高等学校博士点专项科研基金资助课题项目(No.20124323110001)~~

摘　　要：目的:观察针刺结合中药淫羊藿对绝经后骨质疏松症患者生殖内分泌激素及骨代谢的影响,探讨针药结合治疗绝经后骨质疏松症的作用机制。方法:选择年龄在50-70岁符合诊断标准的绝经后骨质疏松症患者30例,每日给与针刺治疗1次(三阴交双、肾俞双、脾俞双、大杼、命门),每次30min;并分别于早、中、晚口服淫羊霍胶囊各1粒(相当于生药1.6g/粒)。所有治疗10d为1个疗程,共3个疗程。分别于治疗前后检测患者1-4腰椎骨密度,静脉血卵泡刺激素、雌二醇、黄体生成素、睾酮、降钙素、甲状旁腺激素、骨钙素。结果:治疗后骨密度较治疗前显著提高(P<0.05);治疗后生殖内分泌激素卵泡刺激素、雌二醇含量较治疗前显著提高(P<0.05);治疗后钙调节激素骨钙素、甲状旁腺激素、降钙素水平较治疗前显著提高(P<0.05)。结论:针药结合对绝经后骨质疏松症患者生殖内分泌激素分泌具有一定的补偿作用;可以增加成骨细胞活性,促进成骨细胞生长,减弱破骨细胞活性,纠正骨代谢负平衡状态。Objective： To observe the effects of acupuncture combined with traditional Chinese medicine Epimedium on procreate-endocrine hormone and bone metabolism in postmenopausal osteoprosis and discuss the mechanism of acupuncture combined with traditional Chinese medicine Epimedium for postmenopausal osteoporosis. Methods： According with diagnostic criteria, 30 postmenopausal osteoprosis patients aged 50-70 were selected. Each patient accepted acupuncture treatment [Sanyinjiao （SP6）, Shenshu （BL23）, Pishu （BL20）, Dazhu （BL11）, Mingmen （DU4）] 30 minutes once a day and one Epimedium capsule 3 times per day. 10-day treatment as a course, every patient accepted 3 courses. Bone mineral density of L1-4, follicle-stimulating hormone, estradiol, luteinizing hormone, testosterone, calcitonin, parathormone and bone GLA protein in postmenopausal osteoporosis patients were detected before and after treatment. Results： After treatment, the bone mineral density of the lumbar vertebra was higher than that before, with the significant statistical difference （P〈0.05）. The procreate-endocrine hormone follicle- stimulating hormone, estradiol and calcitonin, parathormone and bone GLA protein in postmenopausal osteoprosis patients were higher than that before （P〈0.05）. Conclusion： Acupuncture combined with traditional Chinese medicine Epimedium could compensate the lower procreate-endocrine hormone, increase the activity of osteoblast, promote the development of osteoblast, weaken the activity of osteoclast, and correct the negative balance of bone metabolism in postmenopausal osteoporosis patients.

关 键 词：针灸 中医 中药 绝经后骨质疏松症 内分泌 骨代谢 

分 类 号：R259[医药卫生—中西医结合]