加味归脾汤治疗心脾虚损型早泄临床疗效观察  

Clinical Observation of Jiawei Guipi Decoction in Treating Premature Ejaculation with Qi Deficiency of Heart and Spleen

作　　者：邓灵[1] 尹霖[2] 黎杰运[2] 温志鹏[2] 程波敏[2] 张燕[2] 

机构地区：[1]深圳市中医院,广东深圳518033 [2]广州中医药大学,广东广州510405

出　　处：《辽宁中医药大学学报》2014年第7期191-194,共4页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:观察加味归脾汤治疗心脾虚损型早泄的临床疗效,进一步证实早泄从心论治的科学性及有效性,希冀能为早泄的中医药治疗提供科学有效的辨治思路及用药指导。方法:本研究将以射精潜伏期(IELT)、中国早泄患者性功能评价表(CIPE-5)及中医症状积分表的评分作为评估指标。105例符合诊断标准及纳入标准的早泄患者采用区组随机化方法随机分配到治疗组(G1)、对照组I(G2)、对照组II(G3)。G1组采用加味归脾汤进行治疗;G2组采用归脾丸进行治疗;G3组采用西药盐酸曲唑酮进行治疗,疗程均为4周。治疗前后分别记录每位患者的射精潜伏期(IELT),且所有患者将依据中国早泄患者性功能评价表(CIPE-5)及中医症状积分表进行评分,并记录G1、G2及G3组不良反应的发生情况。结果:治疗后,G1组的总有效率明显高于对照组G2及G3组(P<0.05);3组均可延长患者的IELT以及提高CIPE-5评分,但G1组的作用效果明显要优于G2及G3组;G1及G2组的中医症状积分较治疗前明显降低(P<0.05),且G1组的作用效果较G2组更加明显(P<0.05),而G3组治疗前后的中医症状积分对比变化不大(P>0.05);G1组不良反应的发生情况明显要低于G2及G3组(P<0.05)。结论:加味归脾汤不仅能够显著延长早泄患者的射精潜伏期(IELT),提高CIPE-5评分,并降低中医症状积分,还可明显改善早泄患者的临床症状,提高其生活质量及"性福"指数;早泄从心论治思路科学、疗效确切,可供临床选择及借鉴。Objective ： The objective of this study was to make a deep research, system of sorting and comprehensive summing up of premature ejaculation＇s pathogenesis in traditional medicine and modern medicine. By investigating the pathogenesis of premature ejaculation, this research was to prove the heart＇s main status of the therapy and observe Jiawei Guipi Decoction＇s clinical efficiency and side effects. And the validity of Chinese method of calming the heart and tranquilizing the mind may be proved. Finally we looked forward an effective treatment of traditional medicine for premature ejaculation. Metbods：IELT, CIPE-5 and TCM symptoms of measurements were used as the assessment＇s index. 105 patients were randomly divided into the treatment group （ G1 ）, control group Ⅰ （ G2 ） and control group Ⅱ （ G3 ）. The treatment group （ G1 ） was treated by Jiawei Guipi Decoction and control group Ⅰ （ G2 ） by Guipi Decoction, and control groupⅡ （ G3 ） by trazodone hydrochloride for 4-week treatment. We recorded patients＇ IELT before and after the treatment and analyzed the results by the CIPE-5 and TCM symptoms. We also noted adverse drug reaction of those three groups. Results ： （1） Baseline characteristics were well balanced among the G1, G2 and G3 groups （ P〉0.05 ）. There was no significant difference in age, clinical course, clinical type, IELT, CIPE-5＇s level, TCM symptoms of measurements. （2）After 4-week therapy, the G1 group＇s IELT level increased from（ 0.49 ± 0.35 ） min to （ 3.78 ±1.43 ）rain （ P〈0.05 ）. The CIPE-5 level increased from （ 8.95 ±1.84 ）score to （ 17.53 ±4.56 ） score （ P〈0.05 ）. The G3 group＇s IELT level increased from （ 0.53 ± 0.34 ）rain to （ 3.52 ±1.52 ）rain （ P〈0.05 ）. The CIPE-5 level increased from （ 8.75 ± 2.84 ） score to （ 18.45 ± 4.63 ） score （ P〈0.05 ）. After treatmem, the levels of IELT and CIPE-5 scores showed significant difference among G1, G2 and G3 groups （P〈0.05

关 键 词：从心论治 早泄 心脾虚损 加味归脾汤 中医症状积分 

分 类 号：R256.55[医药卫生—中医内科学]