不同物种诱导性多潜能干细胞研究进展及应用  

Progress in Induced Pluripotent Stem Cells of Different Species

作　　者：边艳超[1,2] 牧仁[1,3] 李云章[4] 关伟军[1] 马月辉[1] 

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]内蒙古医科大学基础医学院,内蒙古呼和浩特010059 [3]内蒙古师范大学生命科学与技术学院,内蒙古呼和浩特010022 [4]内蒙古农业大学兽医学院,内蒙古呼和浩特010018

出　　处：《现代生物医学进展》2014年第20期3960-3963,共4页Progress in Modern Biomedicine

基　　金：农业部转基因生物新品种培育科技重大专项(2011ZX08009-003-006;2011ZX08012-002-06)

摘　　要：将特定的转录因子转入细胞并使其重编程后,获得与胚胎干细胞极其相似的多潜能性干细胞,称为诱导性多潜能干细胞(induced Pluripotent Stem Cells,iPS),它是由日本Yamanaka研究小组首次构建并命名。iPS细胞具有极强地自我更新和多项分化潜能,有发育和分化形成机体内几乎所有组织细胞类型的潜能,从而构成机体各种复杂的组织器官,且避免了在伦理、道德、宗教、法律和免疫排斥等诸多问题。随着iPS技术的不断发展,不同物种的iPS细胞相继产生,为细胞代替治疗、疾病模型的建立和药物筛选及再生医学等注入了新的活力。目前,iPS细胞的研究尚处于初级阶段,在临床应用上还存在诸多问题,本文将对近年来不同物种iPS细胞的产生、应用,及我们未来面临的问题和挑战进行综述。The the pluripotent stem cells which are very similar with embryonic stem cells and obtained by transcribing the specific transcription factors into the cells and reprogramrning, were known as the induced pluripotent stem cells （iPS）. It was built and named by Yamanaka team from Japan. The iPS cells have extremely self-renewal and multiple differentiation. Development and differentiation to form all types cell of the body, so as to constitute to complex tissues and organs. The iPS cells also avoid the ethical, moral, religious, legal, immune rejection and many other issues. With the iPS technology evolving, the iPS cells of different species have generated. The iPS cells for cell replacement therapy, establishment of disease models, drug screening and regenerative medicine has injected vitality. Currently, the technology of iPS is still in primary stage. There are still many problems in the preparation and clinical application. This article will review the generation and application of iPS cells of different species, and we will face problems and challenges.

关 键 词：诱导性多潜能干细胞 不同物种 再生医学 临床应用 

分 类 号：Q813.5[生物学—生物工程]