纤维连接蛋白在诊断心肌梗死的特异性研究  

Study on the fibronectin for the diagnosis of myocardial infarction

作　　者：胡丙杰[1] 陈玉川[1] 祝家镇[1] 李军[2] 毕启明[1] 李杰 曾家乐 

机构地区：[1]中山医科大学法医病理学教研室,广东广州510089 [2]中山市公安局坦洲分局,广东中山528467 [3]东莞市公安局法医室,广东东莞511700

出　　处：《中国法医学杂志》2001年第1期23-25,共3页Chinese Journal of Forensic Medicine

基　　金：卫生部科科研基金! (96 -1-12 7);广东省自然科学基金! (980 0 78);卫生部优秀青年科技人才专项基金!(970 0 12 );广东省医药卫生

摘　　要：探讨纤维连接蛋白 (Fn)对心肌梗死死后诊断的特异性。应用免疫组织化学和图像分析技术 ,对正常心脏、心肌梗死及其它非梗死性因素 ,如心肌炎、窒息、电击死、出血性休克、心挫伤、有机磷中毒等 ,直接或间接引起心脏损害时心肌细胞内Fn的变化进行研究。结果发现 :Fn仅在心肌梗死与心肌炎病例出现阳性反应 ,其阳性反应面积同正常对照组存在显著性差异 ,在窒息、电击死、出血性休克、心挫伤、有机磷中毒等病例未见明显阳性反应。Fn作为心肌梗死死后诊断指标仅受心肌炎的影响 。In order to explore the value of fibronectin (Fn) in the postmortem diagnosis of myocardial infarction.The changes of Fn staining in normal, infarcted and other non infarcted myocardial injuries resulted from myocarditis, mechanical asphyxia, electrocution, hemorrhagic shock, cardiac contusion and organophosphate poisoning were studied with immunohistochemistry and image analysis system. The results showed that positive Fn staining could only be observed in groups of myocardial infarction and myocarditis, but could not be found in groups of mechanical asphyxia, electrocution, hemorrhagic shock, cardiac contusion, organophosphate poisoning. It is indicated that positive reaction of Fn could be affected only by myocarditis, so it is quite specific for the diagnosis of myocardial infarction.

关 键 词：心肌梗死 纤维连接蛋白 免疫组织化学 图像分析 

分 类 号：R542.22[医药卫生—心血管疾病]