癌症光动力治疗和新抗癌光敏剂华卟啉钠  

Photodynamic therapy for cancer treatment and the new antitumor photosensitizer sinoporphyrin sodium

作　　者：方起程[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《中国新药杂志》2014年第13期1540-1545,共6页Chinese Journal of New Drugs

基　　金：国家十二五"重大新药创制"科技重大专项(2012ZX09103101-052)

摘　　要：光动力疗法是治疗肿瘤的一种很有前景的新疗法,包括光敏剂和可见光两种因素。将光敏剂注入患者体内后,会很快富集于肿瘤组织,再用特定波长的可见光照射肿瘤病变组织,光敏剂会产生致死性的细胞毒剂(单态氧),杀死肿瘤细胞,同时使肿瘤组织的微血管完全封闭使其营养枯竭,从而导致肿瘤组织坏死。近年来,由于新一代光敏剂(单一的化合物)的创制发明,使光动力疗法治疗恶性肿瘤发展到一个新阶段。在学习、改进、创新的思想指导下,我们对第1代光敏剂Photofrin进行了系统剖析和研究,从中找出了3个有效成分,其光敏活性几乎相同,但比Photofrin强10倍,选择其中之一成分开发成了新型光敏剂华卟啉钠(sinoporphyrin sodium),它将成为我国在抗癌光敏剂领域里有中国知识产权、高效低毒、可产业化生产的新一代高纯度的光敏剂。Photodynamic therapy （PDT） is a promising new cancer treatment. This therapy involves the combination of a photosensitizer and visible light. When the photosensitizer is injected into the patient, it will be soon enriched in tumor tissue while the tumor tissue is irradiated with light of a specific wavelength. It can produce lethal cytotoxic agents （singlet oxygen） and inactivate tumor cells, and in the meantime completely close the tumor microvessels depleting nutritional supply ; thereby cause tumor necrosis. In recent years, some next generation photosensitizers （single compound） were created and produced, so that photodynamic therapy of malignant tumors progressed to a new stage. Under the guidance of study, improvements and innovative ideas, we systematically analyzed and researched the first-generation photosensitizer photofrin. We have found three active ingredients. They have almost the same sensitive activities, but are 10 times stronger than photofrin. In order to meet the needs of the ideal photosensitizer, we selected one of them to develop into a new photosensitizer, named sinoporphyrin sodium. Sinoporphyrin sodium possesses Chinese intellectual property rights, and has high efficiency and low toxicity. It can be industrially produced as a high-purity photosensitizer of next generation.

关 键 词：光动力疗法 癌症 光敏剂 单态氧 PHOTOFRIN 华卟啉钠 

分 类 号：R979.1[医药卫生—药品]