基于药性组合模式的托吡酯新功能发现及其作用机制研究  

Discovery of topiramate's new functions based on medicinal property combinations and study on its mechanism

作　　者：李光霁[1] 顾浩[1] 郭维嘉[1] 张燕玲[1] 王耘[1] 乔延江[1] 

机构地区：[1]北京中医药大学中药信息工程研究中心,北京100102

出　　处：《中国中药杂志》2014年第13期2396-2399,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81373985;81173568);教育部新世纪优秀人才支持项目(NECT-11-0605);国家科技支撑计划项目(2008BAI51B01);北京中医药大学科研创新团队支持项目(2011-CXTD-11)

摘　　要：目的:根据药性组合模式,研究托吡酯的新功能,将中药药性理论用于老药新用途的发现。方法:根据《中药新家族——化学中药》找出托吡酯的药性,再根据糖尿病、高血压、癫痫、肺癌4种疾病的治则治法,依据功效与药性组合关系及总结其对应的药性组合模式将托吡酯的药性组合与各疾病所对应的药性组合进行比较,预测托吡酯的新功能。结果:经过比较,发现所对应的药性组合与托吡酯的药性组合相符,并有相应文献佐证,而其他几种则没有。结论:该文基于药性组合模式,通过中医临床经验,进行托吡酯新功能的筛选,发现托吡酯除对癫痫有治疗作用外,对糖尿病、高血压、肺癌亦有作用,根据药性组合模式探究药物新功能,可大大缩短新药研发的时间。Objective： To study topiramate＇s new functions according to the medicinal property combinations, in order to apply the traditional Chinese medicinal theory in discovering new purposes of old drugs. Method： According to New Traditional Chinese Me- dicinal Families--Chemical Traditional Chinese Medicines, the authors found out topiramate＇s property. Then based on the therapeutic principle of diabetes, hypertension, epilepsy and lung cancer, as well as the relations of efficacies and medicinal property combina- tions, they summarized the corresponding medicinal property combination modes, compared topiramate＇s medicinal property combina- tion mode with corresponding medicinal property combination modes of these diseases, and predict topiramate＇s new functions. Result： According to the comparison, the corresponding medicinal property combinations were consistent with topiramate＇s medicinal property combinations as evidenced by corresponding literatures, whereas other medicinal property combinations were not. Conclusion： Based on medicinal property combination modes, the authors screened topiramate＇s new functions according to e of TCM clinical experience, discovered topiramate＇s therapeutic effects on diabetes, hypertension and lung cancer in addition to epilepsy, and explore new drug function according to medicinal property combination modes, which could help greatly shorten the new drug R＆D period.

关 键 词：药性组合 托吡酯 新功能 气阴两虚型肺癌 阴虚阳亢型高血压 肺热津伤型糖尿病 气阴亏虚型糖尿病 

分 类 号：R259[医药卫生—中西医结合]