胶态二氧化硅和多孔二氧化硅作为黄芩苷固体分散载体的比较  

Compared with colloidal silica and porous silica as baicalin solid dispersion carrier

作　　者：严红梅[1,2] 丁冬梅[1] 汪晶[1] 孙娥[1] 贾晓斌[1,2] 张振海[1] 

机构地区：[1]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028 [2]南京中医药大学,江苏南京210046

出　　处：《中国中药杂志》2014年第13期2484-2488,共5页China Journal of Chinese Materia Medica

基　　金：国家"十一五"科技支撑计划项目(2008BAI51B03)

摘　　要：目的:以黄芩苷作为模型药物,比较胶态二氧化硅与多孔二氧化硅作为其固体分散体载体的溶出特性。方法:将胶态二氧化硅、多孔二氧化硅作为载体,用溶剂法制备黄芩苷固体分散体,进行体外溶出试验,扫描电镜法、差示扫描法、X-射线衍射法鉴别固体分散体的形成。结果:黄芩苷与胶态二氧化硅、多孔二氧化硅制成的固体分散体均能达到快速释放的目的,且随着载体比例的增加,释放加快,60 min内累积释放达80%以上;黄芩苷以非晶体形态分散在固体分散体中。结论:2种载体的释放行为不同,相同比例的这2种固体分散体中,60 min内多孔二氧化硅的溶出度慢于胶态二氧化硅的;60 min后,二者的溶出度接近。Objective： To compare the dissolution characteristics of colloidal silica and porous silica as the solid dispersion carrier, with baicalin as the model drug. Method： The baicalin solid dispersion was prepared by the solvent method, with colloidal silica and porous silica as the carriers. In the in vitro dissolution experiment, the solid dispersion was identified by scanning electron mi- croscopy, differential scanning and X-ray diffraction. Result： The solid dispersion carriers prepared with both colloidal silica and porous silica could achieve the purpose of rapid release. Along with the increase in the proportion of the carriers, the dissolution rate is accelerated to more than 80% within 60min. Baicalin existed in the solid dispersion carriers in the non-crystalline form. Conclusion： The release behaviors of the baicalin solid dispersion prepared with two types of carrier were different. Among the two solid dispersion carriers, porous silica dissolved slowly than colloidal silica within 60 min, and they showed similar dissolutions after 60 min.

关 键 词：黄芩苷 粉体载体 胶态二氧化硅 多孔二氧化硅 

分 类 号：R283[医药卫生—中药学]