效核四联法开展新药创制与中医临床药学的结合度分析  

Combination analysis of new drug discovery with “Xiaohe Silian″ method and traditional Chinese medicine clinical pharmacy

作　　者：刘洋[1] 翟华强[1] 项佳媚 王晶娟[1] 赵保胜[1] 王刚 董红环[1] 欧阳国庆[1] 

机构地区：[1]北京中医药大学,北京100102 [2]中财瀚熙(北京)生物科技发展有限公司,北京100055

出　　处：《中国中药杂志》2014年第13期2583-2587,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81274042);财政部公益性行业科研专项(201407013)

摘　　要：效核四联法是以药效为核心,由"代效、毒效、质效、构效"组成的新药创制模式和方法,其内涵与中医临床药学要求一致。该研究将中药新药创制实践过程的研究方法系统化总结归纳,但为防止中药新药研究的西药化,而进行了中医临床药学结合度的分析。该研究将效核四联法的基本要素分别与中医临床药学进行关联分析,以保证该方法从各个角度与中医临床的紧密结合。因此,该方法坚持多成分研究的整体观,坚持产生疗效时的代谢过程运动观,坚持成分质量控制与构效阐述的分子物质观,为中医临床药学为根基的中药现代新药创制提供新方法。With the kernel of efficacy, ＂Xiaohe Silian＂ was a pattern and method for new drug discovery which was constituted with ＂metabohsm-efficacy, toxicity-efficacy, quality-efficacy and structure-efficacy＂. Its connotation was in keeping with traditional Chi- nese medicine （TCM） clinical pharmacy. This paper systematically summarized the research method of new drug discovery practice process for TCM. To avoid western drug like in TCM new drug discovery, we carried out combination analysis with TCM clinical phar- macy. The correlation analysis between basic elements of ＂Xiaohe Silian＂ and TCM clinical pharmacy was studied to guarantee this method could integrate closely with TCM clinic from all angles. Hence, this method aimed to provide a new method for TCM new drug discovery on the basis of TCM clinical pharmacy with insisting on holistic view of multicomponent study, kinetic view of metabolic process when the curative effect occurred and molecular material view of quality control and structure-activity exposition.

关 键 词：效核四联法 新药创制 中医临床药学 结合度 

分 类 号：R288[医药卫生—中药学]