慢性束缚应激对大鼠血压和血管内皮功能的影响  

Effects of Chronic Immobilization Stress on Blood Pressure and Vascular Endothelial Function in Rats

作　　者：李炎坤[1] 张小梅[2] 李勇[3] 叶娟娟[1] 李锋[1] 李向华[1] 

机构地区：[1]湖北科技学院药学院,湖北咸宁437100 [2]荆州市第一人民医院心内科 [3]湖北科技学院医药研究院

出　　处：《湖北科技学院学报（医学版）》2014年第3期185-187,共3页Journal of Hubei University of Science and Technology(Medical Sciences)

基　　金：湖北省教育厅项目(B2013052);湖北科技学院博士启动基金项目(BK1208);湖北科技学院糖尿病专项课题(ZX1206);湖北科技学院校级青年科研项目(KY11091;KY11092)

摘　　要：目的探讨慢性束缚应激对大鼠血压和血管内皮功能的影响。方法 SD大鼠随机分为对照组和应激组,每组10只。应激组大鼠每天被置于不能自由活动的固定器内束缚2 h,1次/d,连续21 d,最后一次应激结束后24 h分别测定各组大鼠自发活动、动脉血压、血管张力和血浆一氧化氮(NO)含量。结果与对照组比较,应激组大鼠自发活动明显减少(P<0.05),血管收缩压明显升高(P<0.05),血管舒张功能和血浆NO含量明显下降(P<0.01或P<0.05)。结论慢性束缚应激可致血管内皮功能障碍,进而促进高血压等心血管疾病的发生。Objective To observe the effects of chronic immobilization stress on blood pressure and vascular endothelial function in rats .Methods 20 SD rats were randomly divided into two groups , control group and stress group,10 rats in each group.Rats in the stress group were subjected to immobilization stress 2h/d for 21 d using a restrainer .24 h after the last stress ,rats in the two groups were used to measure the locomotive activity,the arterial blood pressure,vascular tone and plasma nitric oxide （NO） level,respectively.Results Compared with the control group,the locomotive activity of the stress group was markedly decreased （P〈0.05）, systolic blood pressure was significantly increased （P〈0.05）,while the vascular diastolic function and the plasma NO level were markedly decreased （ P〈0 .01 or P〈0 .05 ） .Conclusion Chronic immobilization stress can induce vascular endothelial dysfunction which contributes to the development of hypertension and other car -diovascular diseases .

关 键 词：束缚应激 血压 血管内皮功能 一氧化氮 自发活动 

分 类 号：R338[医药卫生—人体生理学]