Prognostic value of coronary artery calcium score in patients with stable an-gina pectoris after percutaneous coronary intervention  

作　　者：Fang-Fang WANG Jiang-Li HAN Rong HE Xiang-Zhu ZENG Fu-Chun ZHANG Li-Jun GUO Wei GAO 

机构地区：[1] Department of Cardiology, Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptide, Ministry of Health Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, China [2] Department of Radiology, Peking University Third Hospital, Beijing 100191, China

出　　处：《Journal of Geriatric Cardiology》2014年第2期113-119,共7页老年心脏病学杂志（英文版）

摘　　要：Objectives To evaluate the prognostic value of the coronary artery calcium （CAC） score in patients with stable angina pectoris （SAP） who underwent percutaneous coronary intervention （PCI）. Methods A total of 334 consecutive patients with SAP who underwent first PCI following multi-slice computer tomography （MSCT） were enrolled from our institution between January 2007 and June 2012. The CAC score was calculated according to the standard Agatston calcium scoring algorithm. Complex PCI was defined as use of high pressure bal-loon, kissing balloon and/or rotablator. Procedure-related complications included dissection, occlusion, perforation, no/slow flow and emer-gency coronary artery bypass grafting. Main adverse cardiac events （MACE） were defined as a combined end point of death, non-fatal myo-cardial infarction, target lesion revascularization and rehospitalization for cardiac ischemic events. Results Patients with a CAC score〉300 （n=145） had significantly higher PCI complexity （13.1%vs. 5.8%, P=0.017） and rate of procedure-related complications （17.2%vs. 7.4%, P=0.005） than patients with a CAC score≤300 （n=189）. After a median follow-up of 22.5 months （4-72 months）, patients with a CAC score≤300 differ greatly than those patients with CAC score＆gt;300 in cumulative non-events survival rates （88.9 vs. 79.0%, Log rank 4.577, P=0.032）. After adjusted for other factors, the risk of MACE was significantly higher [hazard ratio （HR）：4.3, 95%confidence inter-val （95%CI）：2.4-8.2, P=0.038] in patients with a CAC score〉300 compared to patients with a lower CAC score. Conclusions The CAC score is an independent predictor for MACE in SAP patients who underwent PCI and indicates complexity of PCI and proce-dure-related complications.

关 键 词：Angina  Coronary angiography Multi-slice computed tomography Heart catheterization Vascular calcification 

分 类 号：S858.28[农业科学—临床兽医学] Q954.561[农业科学—兽医学]