HBx基因在乙型肝炎病毒相关性肾炎致病机制中的研究进展  

Research progress on HBx gene in pathogenesis of hepatitis B virus-associated glomerulonephritis

作　　者：蒋伟[1] 董晖[1] 马瑞霞[1] 关广聚[2] 

机构地区：[1]山东省青岛大学附属医院肾病科,266003 [2]山东大学第二医院肾病科

出　　处：《中华临床感染病杂志》2014年第3期277-281,共5页Chinese Journal of Clinical Infectious Diseases

基　　金：山东省高等学校科技计划项目（J11LF21）

摘　　要：HBx基因是一种多功能的调节因子,具有广泛的反式激活作用,能激活转录因子、抑制DNA修复,并调节细胞的增殖、转化及凋亡.近年来,HBx在乙型肝炎病毒相关性肾炎（HBV-GN）致病中的作用成为研究的热点.研究显示,HBx对肾小球系膜细胞增殖、足细胞及肾小管上皮细胞的损伤及凋亡存在广泛影响.此文就HBx的生物学特性及在肾脏损伤机制中的研究进展进行了综述.HBx gene is a multifunctional regulator,which has extensive trans-activating effects,and can activate transcription factors,inhibit DNA repair and regulate cell proliferation,differentiation and apoptosis.In recent years,the role of HBx gene in pathogenesis of hepatitis B virus-associated glomemlonephritis （HBV-GN） has been extensively studied,and the results show that HBx can promote glomerular mesangial cell proliferation,and induce damage or apoptosis of podocytes and renal tubular epithelial cells.This paper reviews the research progress on biological characteristics of HBx and its role in pathogenesis of HBV-GN.

关 键 词：肾小球肾炎 HBX基因 发病机制 

分 类 号：R51[医药卫生—内科学] R692[医药卫生—临床医学]