阳离子抗菌肽的研究进展  

Research Advances in Cationic Antimicrobial Peptides

作　　者：武朋朋[1] 杨欢[1] 沈子龙[1] 吴国球[2] 奚涛[1] 

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210009 [2]东南大学附属中大医院检验科,江苏南京210009

出　　处：《药物生物技术》2014年第1期67-70,共4页Pharmaceutical Biotechnology

基　　金：国家自然科学基金资助项目(No.30970809)

摘　　要：抗菌肽(Antimicrobial peptides)是来自生物体内经诱导产生的一类具有抗菌活性的多肽类物质,大多数为阳离子抗菌肽。与传统的抗生素相比,阳离子抗菌肽具有抗菌谱广、毒副作用较低、热稳定性好、抗菌机理独特等优点。结合当今阳离子抗菌肽的研究现状及其进展,从理化性质、结构特征、生物活性及其设计合成等方面对阳离子抗菌肽进行了综述。Antimicrobial peptides,generated by induction in vivo,were a kind of peptides with antibacterial activity to protect organisms from extrogenous pathogen infection.Most of them were cationic antimicrobial peptides.Compared with conventional antibiotics,the peptides shared the common features such as wide antibacterial spectrum,low toxicity and side effects,excellent heat steadiness,and special antibacterial mechanism.Based on the research progress,the physicochemical properties,structural features,biological activity,design and synthesis of cationic antimicrobial peptides were reviewed.

关 键 词：阳离子抗菌肽 结构特征 来源 分类 生物活性 设计合成 

分 类 号：Q516[生物学—生物化学]