老年男性采用单精子卵泡浆内注射（ICSI）治疗结果分析  

Effects of paternal age on intracytoplasmic sperm injection outcome

作　　者：江峰[1] 彭献东[1] 陈华[1] 陈国武[1] 孙晓溪[1] 赵伟鹏[1] 

机构地区：[1]上海集爱遗传与不育诊疗中心,上海200011

出　　处：《中国男科学杂志》2014年第5期34-36,共3页Chinese Journal of Andrology

摘　　要：目的：回顾性分析老龄男性对单精子卵泡浆内注射（ICSI）结果影响。方法将男性患者分成两组，平均年龄（64±3）岁以上为研究A组（27例），平均年龄（35±2）岁为对照B组（54例），该两组的女性配偶平均年龄相仿。结果两组之间的受精率无明显统计学差异（75.3%与82.4%），但B组的临床妊娠率要明显高于A组（P＜0.01），但仍需要更多研究。另外A组患者精液分析显示精液量、精子浓度、正常精子形态率均明显低于B组（P＜0.05），但这并不影响卵子的受精率。结论男性年龄会影响ICSI治疗后的临床妊娠率。Objective To investigate the effects of advanced paternal age on intracytoplasmic sperm injection outcome. Methods There were two age groups of men in the study including Group A（n=27, with a mean age of 64± 3 years） and Group B（n=54, with a mean age of 35±2 years）. The ages of female partners were matched between the two groups. Results： There was no significant difference in fertilization rate between the two groups （75.3 versus 82.4%）. There was a significantly higher pregnancy rate in younger men group （P〈0.01）. However, the long-term outcome of these pregnancies needs further investigation. Semen analysis showed that semen volume,sperm concentration and sperm morphology in Group A than that in Group B （P〈0.05）, but these changes did not affect the fertilization rate. Conclusion：Advance paternal age might have an effect on the pregnancy rate after ICSI.

关 键 词：精子注射  细胞质内 年龄因素 妊娠 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]