古钩藤茎叶的化学成分研究  

Chemical constituents from stems and leaves of Cryptolepis buchananii

作　　者：李江玲[1,2] 赵云丽[1] 秦徐杰[1,2] 刘亚平[1] 罗晓东[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201 [2]中国科学院大学,北京100049

出　　处：《中草药》2014年第12期1677-1681,共5页Chinese Traditional and Herbal Drugs

基　　金：国家科技支撑计划(2013BAI11B02)

摘　　要：目的研究民族药用植物古钩藤Cryptolepis buchananii茎叶的化学成分。方法采用硅胶、Sephadex LH-20、ODS柱色谱以及制备HPLC等手段分离并纯化化合物,通过NMR、MS等波谱技术并结合文献数据鉴定化合物结构。结果从古钩藤茎叶甲醇提取物的醋酸乙酯部分共分离得到13个化合物,分别鉴定为异莨菪亭(1)、(+)-3-hydroxy-β-ionone(2)、(3R,6R,7E)-3-hydroxy-4,7-megastigmadien-9-one(3)、ficusic acid(4)、(+)-松脂素(5)、(+)-8-羟基松脂素(6)、(+)-丁香脂素(7)、异橙黄胡椒酰胺乙酸脂(8)、loliolide(9)、(–)-蛇菰宁(10)、金圣草素(11)、9-hydroxy-10E,12Z-octadecadienoic acid methyl ester(12)和ficusesquilignan A(13)。结论所有化合物均为首次从该属植物中分离得到。Objective To study the chemical constituents from the stems and leaves of Cryptolepis buchananii. Methods Compounds were isolated and purified by chromatography on silica gel, Sephadex LH-20, ODS columns, and preparative HPLC. Their structures were identified by NMR and MS, as well as comparison on spectral data with literature values. Results Thirteen compounds were obtained from the EtOAc fraction of methanol extract in the stems and leaves of C. buchananii and their structures were elucidated as isoscopoletin （1）, （＋）-3-hydroxy-β-ionone （2）, （3R, 6R, 7E）-3-hydroxy-4, 7-megastigmadien-9-one （3）, ficusic acid （4）, （＋）-pinoresinol （5）, （＋）-8-hydroxypinoresinol （6）, （＋）-syringaresinol （7）, diaaurantiamide acetate （8）, loliolide （9）, （-）-balanophonin （10）, chrysoeriol （11）, 9-hydroxy-10E, 12Z-octadecadienoic acid methyl ester （12）, and ficusesquilignan A （13）. Conclusion All the compounds are isolated from the plants of Cryptolepis R. Br. for the first time.

关 键 词：白叶藤属 古钩藤 (+)-松脂素 异橙黄胡椒酰胺乙酸脂 金圣草素 

分 类 号：R284.1[医药卫生—中药学]