阿胶颗粒干法制粒工艺研究  

Study on dry granulation technology for Ejiao granules

作　　者：田守生[1] 孙四海[2] 张淹[1] 辛杰[1] 王春艳[1] 

机构地区：[1]山东东阿阿胶股份有限公司国家胶类中药工程技术研究中心,山东聊城252201 [2]聊城市人民医院,山东聊城252000

出　　处：《中草药》2014年第12期1714-1717,共4页Chinese Traditional and Herbal Drugs

基　　金：重大新药创制科技重大专项"中药大品种阿胶技术改造"(2011ZX09201-201-10);山东省科技发展计划项目(2013G0031901)

摘　　要：目的研究阿胶颗粒干法制粒的最佳工艺条件。方法考察轧轮压力、轧轮转速和送粉速度对颗粒得率的影响,采用L9（34）正交试验优选阿胶颗粒干法制粒工艺条件。结果最佳制粒工艺条件为轧辊压力为60~70 kgf/cm2、送粉速度17~19 r/min、轧轮转速为10~12 r/min。结论阿胶颗粒干法制粒工艺的研究,为阿胶颗粒产业化应用和干法制粒技术在动物类中药中的推广应用提供实验依据。Objective To study the optimal technological conditions of Ejiao granules by dry granulation. Methods The effects of rolling wheel press, speed, and powder feeding rate on grain yield were studied, and the dry granulation technology for Ejiao granules was optimized using L9（34） orthogonal test. Results The optimal granulating conditions for the roll pressure was 60--70 kgf/cm2, powder feeding rate was 17--19 r/min, and rolling speed was 10--12 r/min. Conclusion The study on the dry granulation technology for Ejiao granules provides the experimental basis for industrial application and spread of dry granulation technology in Chinese animal medicines.

关 键 词：阿胶颗粒 干法制粒 正交试验 颗粒得率 动物类中药 

分 类 号：R283.6[医药卫生—中药学]