急性心肌梗死患者早期快速测定血浆N-末端B型利钠肽原的临床价值  

Clinical value of rapid detection of plasma NT-proBNP levels on admission in patients with acute myocardial infarction

作　　者：张春德[1] 张爱萍[1] 陈斌[1] 刘家威[1] 洪德瑞[1] 

机构地区：[1]淮南市第一人民医院心内科,安徽省淮南232007

出　　处：《中国基层医药》2014年第12期1778-1779,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨急性心肌梗死（AMI）患者早期快速测定血浆N-末端B型利钠肽原（NT—proBNP）的水平对临床预后的判断价值。方法选择56例符合诊断的AMI患者，人院早期快速测定血浆NT—proBNP的水平，根据血浆NT-proBNP的水平分成三组：A组〈500ng／L，B组500—2000ng／L，C组〉2000ng／L，观察三组在住院期间、30d发生心血管不良事件情况（严重心律失常、充血性心力衰竭、心源性休克及死亡）。结果三组住院期间、30d发生心血管不良事件情况（A组1例、0例，B组3例、1例，c组8例、6例）明显不同（χ2=6．705，P=0．035；χ2=7．957，P=0．008）。三组发生心血管不良事件发生率呈递增趋势，分别为6．6％．18．18％，73．69％。结论AMI患者早期快速测定血浆NT—proBNP水平，对评估AMI患者近期临床预后及指导治疗具有重要临床价值。Objective To explore the clinical prognostic value of rapid detection for plasma NT-proBNP lev- els on admission in patients with acute myocardial infarction. Methods 56 patients with AMI were measured plasma NT-proBNP imediately ih hospital, and then they were divided into A, B and C group according to NT-proBNP levels （A group： 〈500ng/L,B group：500-2 000ng/L,C group： 〉2 000ng/L）. The incidence of major adverse cardiac e- vents （ MACE including congestive heart failure, malignant arrhythmia, cardiogenic shock and sudden cardiac death） in subjects were observed respectively during hospitalisation and 30 days. Results The three group subjects with differ- ent NT-proBNP levels presented different incidence of MACE （ A group ： 1,0 ; B group ： 3,1 ; C group ： 8,6 ） at duration of hospital stay,30days （ χ2 = 6. 705, P = 0. 035 ; χ2 = 7. 957, P = 0. 008 ）. With the NT-proBNP levels rising in AMI paitents,the inciedence of MACE increased. The incidence of MACE in A,B and C group were 6.6% ,18.18% and 73.69% respectively. Conclusion In AMI patients,plasma NT-proBNP levels could predict early MACE incidence, which has an important value to evaluate the early clinical prognosis.

关 键 词：心肌缺血 肽类激素 

分 类 号：R542.22[医药卫生—心血管疾病]