细辛脑注射液不良反应137例分析  

Literature analysis of 137 adverse drug reaction reports of asarone injection

作　　者：许恒峰 

机构地区：[1]诸暨市人民医院药剂科,浙江省诸暨311800

出　　处：《中国基层医药》2014年第12期1797-1798,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨细辛脑注射液不良反应的发生类型、特点及相关风险因素，为临床合理用药提供参考。方法对1999年1月至2013年6月医药学期刊报道有关细辛脑注射液致不良反应文献进行汇总和分析。结果共检索文献全文142篇，纳入分析的文献72篇，共137例细辛脑注射液所致不良反应，药物不良反应可累积多个系统，以皮肤损害、过敏反应、胃肠道损害最为常见，严重者可致过敏性休克、急性肾功能衰竭；9岁以下患者占60．59％，不良反应发生在30min以内的占81．76％，联合用药时占67．88％。结论细辛脑注射液的不良反应以速发型为主，多发于青少年，并且联合用药时不良反应发生率较高。Objective To explore the types and risk factors of adverse drug reactions （ADRs） induced by Asarone injection so as to provide references for clinical rational use of drug. Methods The ADRs of Asarone injec- tion which reported in domestic medical journal from January 1999-June 2013 were collected and analyzed. Results 72 literatures were picked up from the whole 142 results, 137 cases of Asarone injection were collected. The ADRs of Asarone injection were mainly occurred in children below 9 years old （60.59%）, ADRs can be accumulated and prompted several organ systems to skin damage, such as allergic reactions and gastrointestinal damage, ect. The adverse drug reaction was abrupt and usually oceured within 30 minutes （81.76%）, the combined medication accounted for 67.88%. Conclusion Asarone injection can,cause varies type of ADRs,which happens mainly to the young adults and those use the combination of Asarone injection and other drugs at the same time.

关 键 词：药物毒性 细辛脑注射液 

分 类 号：R288[医药卫生—中药学]