单分散羧基化Fe3O4磁性纳米粒子的制备及表征  

Synthesis and characterization of carboxy-functionalized monodisperse Fe_3O_4 magnetic nanoparticles

作　　者：靳艳艳[1] 程武[1] 王苗[1] 邢艳[1] 彭明丽[1,2] 王小芳[1] 陈超 崔亚丽 

机构地区：[1]西北大学化学与材料科学学院合成与天然功能分子化学教育部重点实验室,西安710069 [2]国家微检测系统工程技术研究中心,西安710069

出　　处：《科学通报》2014年第18期1700-1706,共7页Chinese Science Bulletin

基　　金：国家自然科学基金(21303136);陕西省自然科学基金基础研究计划(2012JQ4026)资助

摘　　要：单分散羧基功能化Fe3O4磁性纳米粒子在生物医学诊断、治疗的基础和应用研究中具有重要的意义.本文在制备油酸稳定的磁性纳米粒子基础上,利用高碘酸钠将其表面油酸充分氧化制备了单分散羧基化Fe3O4磁性纳米粒子.采用傅里叶红外光谱仪(FT-IR)、透射电子显微镜(TEM)、热失重分析(TGA)、X射线粉末衍射仪(XRD)、振动样品磁强计(VSM)等方法对Fe3O4磁性纳米粒子的形貌、大小、组成、磁强度以及分散性进行了表征.结果表明,该磁性纳米粒子在常温下有良好的超顺磁性,表面含有羧基,直径为12 nm,粒径均一,在水中分散良好.利用热重法和4-溴甲基-6,7-二甲氧基香豆素化学反应方法测定其羧基含量均在10-7 mol/mg数量级.The functionalized monodisperse Fe3O4 magnetic nanoparticles are of importance in the field of biomedical detection and therapy. In this paper, the carboxyl-functionalized monodisperse Fe3O4 magnetic nanoparticles were synthesized by first synthesis of the oleic acid stabilized monodisperse iron oxide nanoparticles, and then the oxidation of oleic acid on the surface of the magnetic nanoparticles by sodium periodate. The nanoparticles were characterized by FT-IR, transmission electron microscopy （TEM）, thermogravimetric analyzer （TGA）, X-ray diffraction （XRD） and vibrating sample magnetometer （VSM）. The experiment results show that the Fe3O4 magnetic nanoparticles have been functionalized by carboxyl group, and the diameter was 12 nm with superparamagnetism at room temperature momodisperse and good dispersion in aqueous solution. The concentration of carboxyl group on the surface of these nanoparticles was determined by TGA and 4-bromomethyl-6,7-dimethyloxycoumarin reaction method, respectively, the data show that the concentration of carboxyl group is on the order of 10^-7 mol/mg.

关 键 词：单分散 磁性纳米粒子 氧化 羧基 含量测定 

分 类 号：TB383.1[一般工业技术—材料科学与工程]