11β-羟基类固醇脱氢酶与代谢综合征的相关性  

Correlation between 11β-hydroxysteroid dehydrogenase and metabolic syndrome

作　　者：阮莉莉[1,2] 邹朝春[1] 

机构地区：[1]浙江大学医学院附属儿童医院内分泌科,杭州310003 [2]杭州师范大学附属医院,杭州310015

出　　处：《上海交通大学学报（医学版）》2014年第6期924-928,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：浙江省重点科技创新团队自主立项项目(2010R50045)~~

摘　　要：代谢综合征(MetS)是多种代谢成分异常聚集的病理状态,是导致心血管疾病和糖尿病的危险因素。糖皮质激素失调是MetS的重要特征,11β-羟基类固醇脱氢酶(11β-HSD)在体内主要负责活性糖皮质激素向其无活性前体转换,调节局部糖皮质激素浓度。11β-HSD参与了包括胰岛素抵抗、肥胖、2型糖尿病及高血压在内的MetS的病理生理环节,11β-HSD抑制剂在MetS中的应用将为治疗MetS提供新的途径。Metabolic syndrome （MetS） is a pathological condition of disorders of several metabolic components and a risk factor of causing cardiovascular diseases and diabetes. Dysregulation of glucocorticoid is an important feature of MetS. 11β-hydroxysteroid dehydrogenase （11β-HSD） of the body mainly converts the active glucocorticoid to its inactive precursor and regulates the concentration of local glucocorticoid. 11β-HSD involves pathophysiologic processes of MetS such as insulin resistance, obesity, type 2 diabetes, and hypertension. The application of 11β-HSD1 inhibitors may provide new methods for treating MetS.

关 键 词：代谢综合征 11Β-羟基类固醇脱氢酶 心血管疾病 糖尿病 11β-羟基类固醇脱氢酶抑制剂 

分 类 号：R589[医药卫生—内分泌]