阵发性心房颤动患者窦性停搏的临床意义研究  

Incidence and Clinical Significance of Sinus Pause in Patients with Paroxysmal Atrial Fibrillation

作　　者：周三凤[1,2] 石少波[1,2] 梁锦军[1,2] 曲川[1,2] 王慧[1,2] 杨波[1,2] 

机构地区：[1]武汉大学人民医院心内科 [2]武汉大学心血管病研究所,430060

出　　处：《医学研究杂志》2014年第6期56-59,共4页Journal of Medical Research

基　　金：湖北省自然科学基金资助项目(2011CDC157)

摘　　要：目的研究阵发性心房颤动患者窦性停搏的发生率,并探讨其临床意义。方法纳入阵发性心房颤动患者64例(心房颤动组)和健康体检者80例(对照组)均进行24h动态心电图检查,记录各组大于2.0秒的窦性停搏的人数、次数和最长停搏时间,比较两组的差异,根据有无发生窦性停搏将心房颤动组分为事件组和非事件组,随访半年和1年,比较两组患者晕厥发生率的差异。结果心房颤动组窦性停搏发生率显著高于对照组(40.63%vs 0%,P<0.01),停搏时间2.67±0.71s,最长停搏时间为5.3s,停搏次数400.46±297.42次。随访半年,事件组和无事件组晕厥发生率分别是26.92%和0%,随访1年,事件组和无事件组晕厥发生率分别是30.77%和2.63%,差异均有统计学意义(P<0.01)。结论阵发性心房颤动患者窦性停搏的发生率明显高于健康者,阵发性心房颤动并发窦性停搏的患者发生晕厥的危险性及晕厥发生率明显增加。Objective To explore the incidence of sinus pause and to analyze the clinical significance in patients with paroxysmal atrial fibrillation（PAF）. Methods A total of 64 patients with paroxysmal atrial fibrillation （AF group） and 80 healthy pepole （control group） were examined with24h dynamic electrocardiogram. The number of patients with sinus pause, the times of sinus pause and the longest last time were recorded and compared between two groups. Then according to whetherwith sinus pause, the AF group was divided into event group and free - event group. During the followed - up to 6 mouths and 1 year, the incidence of syncope was compared betwcenthese groups. Results The incidence of sinus pause was significant higher in AF group than control group （40.63% vs 0% , P 〈 0.01 ）. The mean time of sinus pause was 2.67 ± 0.71 seconds, the longest time was 5.3 seconds, and the frequency was 400.46 ± 297.42 showed in the AF group. During the follow - up of 6 mouths,the incidence of syncope was higher in event group than free - event group （26.92% vs0% , P 〈 0.01 ）, then during the follow - up of 1 year, the above trend remained not change （ 30.77% vs 2.63% , P 〈 0. 01 ）. Conclusion The incidence of sinus pause is significantly higher in PAF patients than healthy ones, and the risk of syncope is higher in PAF patients with sinus pause than those patients without sinus pause.

关 键 词：阵发性心房颤动 窦性停搏 晕厥 

分 类 号：R5[医药卫生—内科学]