引经药醋柴胡对索拉非尼在大鼠血液和肝脏中药物浓度的影响  

Effects of Medicinal Guide Drug Vinegar Processing Radix Bupleuri on Sorafenib Concentration in Plasma and Liver of Rats

作　　者：何春晓[1,2] 张贝贝[1] 郑蕾[1] 黄翔[2] 艾进超 施思[2] 卢红阳[1] 张沂平[1] 

机构地区：[1]浙江省肿瘤医院化疗中心,杭州310022 [2]浙江中医药大学,杭州310053

出　　处：《医学研究杂志》2014年第6期62-66,共5页Journal of Medical Research

基　　金：浙江省中医药科学研究基金资助项目(2012ZA022)

摘　　要：目的研究引经药醋柴胡对索拉非尼在大鼠血液和肝脏中药物浓度的影响。方法选用健康雄性SD大鼠,随机分为对照组和醋柴胡组。醋柴胡组按醋柴胡的给药剂量分低、中、高(600mg/kg、1200mg/kg、2400mg/kg)3个小组,对照组给蒸馏水,连续灌胃5天后各组均按65mg/kg剂量灌胃索拉非尼。采用高效液相色谱法测定大鼠血浆和肝脏中索拉非尼的药物浓度。结果与对照组相比,醋柴胡组的索拉非尼在肝脏中浓度差异有统计学意义(P<0.05),但在血浆中药物浓度比较,差异无统计学意义(P>0.05)。结论醋柴胡可以增加索拉非尼在大鼠肝脏中的浓度。Objective To research the effects of medicinal guide drug vinegar processing Radix Bupleuri on sorafenib concentration in plasma and liver of rats. Methods Heahhy male SD rats were recruited and randomly divided into control group and vinegar processing Radix Bupleuri group. Vinegar processing Radix Bupleuri group had three group according to the dose of Vinegar processing Radix Bupleuri administered at 600mg/kg, 1200mg/kg and 2400mg/kg. The control group were administered with distilled water. After 5 days con-tinuing gastrogavage with drug, each group were administered with sorafinib at 65mg/kg. The sorafenib concentration in plasma and liver of rats were determinating by Highperformance liquid chromatography. Results Compared with the control group, the sorafenib concentration increased in liver of rats（ P 〈 0.05 ） , while could not increased the concentration in plasma of rats（ P 〉 0.05 ）. Conclusion The vinegar processing Radix Bupleuri could increased the sorafenib concentration in liver of rats.

关 键 词：醋柴胡 索拉非尼 高效液相色谱法 药物浓度 

分 类 号：R285[医药卫生—中药学]